Evidence map›Paper›PMID 36264444›Full record

ArticleJournal of assisted reproduction and genetics2022

Clinical outcome of planned oocyte cryopreservation at advanced age.

Avi Tsafrir, Ido Ben-Ami, Talia Eldar-Geva, Michael Gal, Nava Dekel, Hadassah Levi, Oshrat Schonberger, Naama Srebnik, Amir Weintraub, Doron Goldberg and 1 more

Abstract read
In one paragraph

Article in Journal of assisted reproduction and genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Observational
  4. Nesting the Eggs on Another Day: Social Egg Freezing.Journal of obstetrics and gynaecology of India · 2025
    Review
  5. Article
  6. Observational
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Avi TsafrirIVF Unit, Department of Obstetrics and Gynecology, Shaare Zedek Medical Center, Shmu'el Bait St 12, 9103102, Jerusalem, Israel. avits@netvision.net.il.
Ido Ben-AmiIVF Unit, Department of Obstetrics and Gynecology, Shaare Zedek Medical Center, Shmu'el Bait St 12, 9103102, Jerusalem, Israel.
Talia Eldar-GevaIVF Unit, Department of Obstetrics and Gynecology, Shaare Zedek Medical Center, Shmu'el Bait St 12, 9103102, Jerusalem, Israel.
Michael GalIVF Unit, Department of Obstetrics and Gynecology, Shaare Zedek Medical Center, Shmu'el Bait St 12, 9103102, Jerusalem, Israel.
Nava DekelIVF Unit, Department of Obstetrics and Gynecology, Shaare Zedek Medical Center, Shmu'el Bait St 12, 9103102, Jerusalem, Israel.
Hadassah LeviIVF Unit, Department of Obstetrics and Gynecology, Shaare Zedek Medical Center, Shmu'el Bait St 12, 9103102, Jerusalem, Israel.
Oshrat SchonbergerIVF Unit, Department of Obstetrics and Gynecology, Shaare Zedek Medical Center, Shmu'el Bait St 12, 9103102, Jerusalem, Israel.
Naama SrebnikIVF Unit, Department of Obstetrics and Gynecology, Shaare Zedek Medical Center, Shmu'el Bait St 12, 9103102, Jerusalem, Israel.
Amir WeintraubIVF Unit, Laniado Medical Center and the Rappaport Faculty of Medicine-Technion, Netanya, Israel.
Doron GoldbergClalit Health Services, Fertility clinic, Modi'in Illit, Israel.
Jordana HymanIVF Unit, Department of Obstetrics and Gynecology, Shaare Zedek Medical Center, Shmu'el Bait St 12, 9103102, Jerusalem, Israel.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo report outcome of planned oocyte cryopreservation (POC) in the first 8 years of this treatment in our center.

methodsA retrospective study in a university-affiliated medical center.

resultsA total of 446 women underwent POC during 2011-2018. Fifty-seven (13%) women presented to use these oocytes during the study period (until June 2021). POC was performed at a mean age of 37.9 ± 2.0 (range 33-41). Age at thawing was 43.3 ± 2.1 (range 38-49). A total of 34 (60%) women transferred their oocytes for thawing at other units. Oocyte survival after thawing was significantly higher at our center than following shipping to ancillary sites (78 vs. 63%, p = 0.047). Forty-nine women completed their treatment, either depleting their cryopreserved oocytes without conceiving (36) or attaining a live birth (13)-27% live birth rate per woman. Only one of eleven women who cryopreserved oocytes aged 40 and older had a live birth using thawed oocytes.

conclusionWomen should be advised to complete planned oocyte cryopreservation before age 40, given low success rates in women who underwent cryopreservation at advanced reproductive age. In this study, oocyte shipping was associated with lower survival rate. These findings may be relevant for women considering POC and utilization of cryopreserved oocytes.

Indexed as

CryopreservationEmbryo TransferFemaleHumansMaleOocytesPregnancyPregnancy RateRetrospective StudiesAdvanced maternal ageAge-related infertilityElective oocyte cryopreservationOocyte shippingOocyte thawingOocyte transportationPlanned oocyte cryopreservationSocial egg freezing

Identifiers

PMID36264444
PMCPMC9723084

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.