Evidence map›Paper›PMID 36264420›Full record

SynthesisTranslational stroke research2023

A Genome-Wide Association Study of Outcome After Aneurysmal Subarachnoid Haemorrhage: Discovery Analysis.

Ben Gaastra, Sheila Alexander, Mark K Bakker, Hemant Bhagat, Philippe Bijlenga, Spiros L Blackburn, Malie K Collins, Sylvain Doré, Christoph J Griessenauer, Philipp Hendrix and 15 more

Registry-linked trialAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Translational stroke research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05526352 (@neurIST), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05526352 recruitingnot on this map

@neurIST : Informatique biomédicale intégrée Pour la Gestion Des anévrismes cérébraux

Typeobservational_patient_registrySponsorUniversity Hospital, GenevaRan2015 to 2040Enrolled20,000ConditionsIntracranial Aneurysm
3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Bioinformatics analysis reveals major hub genes involved with extracellular matrix and inflammatory and endocrine pathways associated with intracranial aneurysm tissue.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025
    Article
  3. Article
  4. Review
  5. Metabolomic and lipidomic pathways in aneurysmal subarachnoid hemorrhage.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Ben GaastraFaculty of Medicine, University of Southampton, Southampton, SO17 1BJ, UK.ORCID 0000-0002-7517-6882
Sheila AlexanderSchool of Nursing, University of Pittsburgh, 3500 Victoria Street, Pittsburgh, PA, 15261, USA.ORCID 0000-0001-5866-027X
Mark K BakkerDepartment of Neurology, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Heidelberlaan 100, 3584 CX, Utrecht, the Netherlands.ORCID 0000-0002-7887-9014
Hemant BhagatDivision of Neuroanaesthesia, Department of Anaesthesia and Intensive Care, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.ORCID 0000-0001-9200-9915
Philippe BijlengaNeurosurgery Division, Department of Clinical Neurosciences, Faculty of Medicine, Geneva University Hospitals, Geneva, Switzerland.ORCID 0000-0002-3586-2757
Spiros L BlackburnUniversity of Texas Houston Health Science Center, Houston, TX, USA.ORCID 0000-0003-2902-5079
Malie K CollinsGeisinger Commonwealth School of Medicine, Scranton, PA, USA.ORCID 0000-0002-9553-3824
Sylvain DoréDepartments of Anesthesiology, Neurology, Psychiatry, Pharmaceutics, and Neuroscience College of Medicine, Center for Translational Research in Neurodegenerative Disease, McKnight Brain Institute, University of Florida, Gainesville, FL, USA.ORCID 0000-0003-3771-5109
Christoph J GriessenauerDepartment of Neurosurgery, Geisinger, Danville, PA, USA.ORCID 0000-0002-2952-3812
Philipp HendrixDepartment of Neurosurgery, Geisinger, Danville, PA, USA.ORCID 0000-0003-0017-5049
Eun Pyo HongInstitute of New Frontier Research, Hallym University College of Medicine, Chuncheon, South Korea.ORCID 0000-0001-7789-686X
Isabel C HostettlerStroke Research Centre, Institute of Neurology, University College London, London, UK.ORCID 0000-0002-9004-2540
Henry HouldenStroke Research Centre, Institute of Neurology, University College London, London, UK.ORCID 0000-0002-2866-7777
Koji IIharaNational Cerebral and Cardiovascular Center Hospital, 6-1 Kishibe-Shimmachi, Suita, Osaka, Japan.ORCID 0000-0002-7852-220X
Jin Pyeong JeonInstitute of New Frontier Research, Hallym University College of Medicine, Chuncheon, South Korea.ORCID 0000-0001-8543-6855
Bong Jun KimInstitute of New Frontier Research, Hallym University College of Medicine, Chuncheon, South Korea.ORCID 0000-0003-3374-5554
Jiang LiDepartment of Molecular and Functional Genomics, Weis Center for Research, Geisinger Health System, Danville, Danville, PA, 17822, USA.ORCID 0000-0002-7006-1285
Sandrine MorelNeurosurgery Division, Department of Clinical Neurosciences, Faculty of Medicine, Geneva University Hospitals, Geneva, Switzerland.ORCID 0000-0003-1538-3553
Paul NyquistDepartments of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, 21287, USA.ORCID 0000-0001-6078-3543
Dianxu RenSchool of Nursing, University of Pittsburgh, 3500 Victoria Street, Pittsburgh, PA, 15261, USA.ORCID 0000-0002-1160-8922
Ynte M RuigrokDepartment of Neurology, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Heidelberlaan 100, 3584 CX, Utrecht, the Netherlands.ORCID 0000-0002-5396-2989
David WerringStroke Research Centre, Institute of Neurology, University College London, London, UK.ORCID 0000-0003-2074-1861
Will TapperFaculty of Medicine, University of Southampton, Southampton, SO17 1BJ, UK. W.J.Tapper@soton.ac.uk.ORCID 0000-0002-5896-1889
Ian GaleaFaculty of Medicine, University of Southampton, Southampton, SO17 1BJ, UK.ORCID 0000-0002-1268-5102
Diederik BultersDepartment of Neurosurgery, Wessex Neurological Centre, University Hospital Southampton, Southampton, SO16 6YD, UK.ORCID 0000-0001-9884-9050

Funding

Role of 20-HETE on Vasospasm-Induced Ischemia after Subarachnoid HemorrhageR01NR004339 · NINR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI POLOYAC, SAMUEL M, SHERWOOD, PAULA R · 1999 to 2013
$7.2M
Role of Haptoglobin Genotype on Neuroinflammation and Coagulation Following Aneurysmal Subarachnoid HemorrhageK23NS106054 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BLACKBURN, SPIROS · 2018 to 2022
$875k
Department of HealthMedical Research Council MC_QA137853NINDS NIH HHS K23 NS106054NINR NIH HHS R01 NR004339
6 · The paper itself

Abstract

Candidate gene studies have identified genetic variants associated with clinical outcomes following aneurysmal subarachnoid haemorrhage (aSAH), but no genome-wide association studies have been performed to date. Here we report the results of the discovery phase of a two-stage genome-wide meta-analysis of outcome after aSAH. We identified 157 independent loci harbouring 756 genetic variants associated with outcome after aSAH (p < 1 × 10

Indexed as

Subarachnoid HemorrhageGenome-Wide Association StudyHumansLongitudinal StudiesTreatment OutcomeGenetics, MedicalOutcome assessment, Health careStrokeSubarachnoid haemorrhage

Identifiers

PMID36264420
PMCPMC10444641

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.