Evidence map›Paper›PMID 36264354›Full record

SynthesisClinical neuroradiology2023

Endovascular Therapy in Acute Isolated Posterior Cerebral Artery Occlusion : Systematic Review and Meta-analysis.

Ramy Abdelnaby, Khaled Ashraf Mohamed, Anas ELgenidy, Yousef Tarek Sonbol, Mahmoud Mostafa Bedewy, Aya Moustafa Aboutaleb, Khaled Tarek Dardeer, Hamed Amr Heikal, Hazem Maher Gawish, Omid Nikoubashman and 2 more

Open access · hybridAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Clinical neuroradiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Endovascular thrombectomy for posterior cerebral artery strokes in the national inpatient sample (EaT PeCANpIeS) study.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2026
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Ramy AbdelnabyDepartment of Neurology, University Hospital, University Hospital RWTH Aachen, Pauwelsstr. 30, 52074, Aachen, Germany.
Khaled Ashraf MohamedFaculty of Medicine, Cairo University, Cairo, Egypt.
Anas ELgenidyFaculty of Medicine, Cairo University, Cairo, Egypt.
Yousef Tarek SonbolFaculty of Medicine, Cairo University, Cairo, Egypt.
Mahmoud Mostafa BedewyFaculty of Medicine, Cairo University, Cairo, Egypt.
Aya Moustafa AboutalebFaculty of Medicine, Zagazig University, Zagazig, Egypt.
Khaled Tarek DardeerFaculty of Medicine, Cairo University, Cairo, Egypt.
Hamed Amr HeikalFaculty of Medicine, Cairo University, Cairo, Egypt.
Hazem Maher GawishFaculty of Medicine, Cairo University, Cairo, Egypt.
Omid NikoubashmanDepartment of Diagnostic and Interventional Neuroradiology, University Hospital, RWTH Aachen University, Aachen, Germany.
Arno ReichDepartment of Neurology, University Hospital, University Hospital RWTH Aachen, Pauwelsstr. 30, 52074, Aachen, Germany.
João PinhoDepartment of Neurology, University Hospital, University Hospital RWTH Aachen, Pauwelsstr. 30, 52074, Aachen, Germany. jferreiradep@ukaachen.de.ORCID http://orcid.org/0000-0002-3977-7146
Cairo University · EGRWTH Aachen University · DEUniversitätsklinikum Aachen · DEZagazig University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePatients with isolated posterior cerebral artery occlusion (iPCAO) represent up to 6% of all acute ischemic stroke patients. Acute revascularization therapies for these patients were not tested in randomized controlled trials. The aim of this study was to evaluate outcomes of iPCAO patients who undergo endovascular treatment (EVT).

methodsA systematic search of MEDLINE, Web of Science, CENTRAL, Scopus (inception-03/2022) was conducted for studies reporting 3‑month outcome, symptomatic intracranial hemorrhage (sICH) and/or successful recanalization in iPCAO patients who underwent EVT. Random effect meta-analyses for pooled proportions were calculated. Double-arm meta-analyses for comparison of outcomes of iPCAO patients treated with EVT with age-, sex- and NIHSS-matched iPCAO patients treated with best medical treatment only were performed.

resultsFifteen studies reporting a total of 461 iPCAO patients who underwent EVT were included. Excellent and favorable 3‑month outcome proportions were 36% (95% confidence interval, CI 20-51%) and 57% (95% CI 40-73%), respectively. The 3‑month mortality was 9% (95% CI 5-13), sICH occurred in 1% (95% CI 0-2%), successful recanalization was achieved in 79% (95% CI 71-86%). No significant differences in favorable and excellent 3‑month outcomes, 3‑month mortality and symptomatic intracerebral hemorrhage were found between the groups of patients who underwent EVT and the group of patients who received best medical treatment only.

conclusionThese results support the feasibility and safety of EVT in iPCAO, but do not show an outcome benefit with EVT compared to best medical treatment. Randomized trials are needed to evaluate treatment benefit of EVT in these patients.

Indexed as

Brain IschemiaEndovascular ProceduresIschemic StrokeStrokeHumansIntracranial HemorrhagesPosterior Cerebral ArteryRandomized Controlled Trials as TopicThrombectomyTreatment OutcomeIschemic strokeLarge vessel occlusionOutcomeStrokeThrombectomy

Identifiers

PMID36264354
PMCPMC10220103
OpenAlexW4306909422

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.