Evidence map›Paper›PMID 36264352›Full record

ArticleClinical neuroradiology2023

Quantification and Proximal-to-Distal Distribution Pattern of Tibial Nerve Lesions in Relapsing-Remitting Multiple Sclerosis : Assessment by MR Neurography.

Adriana M Pietsch, Andrea Viehöver, Ricarda Diem, Markus Weiler, Mirjam Korporal-Kuhnke, Brigitte Wildemann, Georges Sam, John M Hayes, Olivia Fösleitner, Johann M E Jende and 3 more

Open access · hybridAbstract read
In one paragraph

Article in Clinical neuroradiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 2 countries.

Adriana M PietschDepartment of Neuroradiology, Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.
Andrea ViehöverDepartment of Neurology, Heidelberg University Hospital, Heidelberg, Germany.
Ricarda DiemDepartment of Neurology, Heidelberg University Hospital, Heidelberg, Germany.
Markus WeilerDepartment of Neurology, Heidelberg University Hospital, Heidelberg, Germany.
Mirjam Korporal-KuhnkeDepartment of Neurology, Heidelberg University Hospital, Heidelberg, Germany.
Brigitte WildemannDepartment of Neurology, Heidelberg University Hospital, Heidelberg, Germany.
Georges SamDepartment of Neurology, Heidelberg University Hospital, Heidelberg, Germany.
John M HayesDepartment of Neurology, University of Michigan, Ann Arbor, USA.
Olivia FösleitnerDepartment of Neuroradiology, Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.
Johann M E JendeDepartment of Neuroradiology, Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.
Sabine HeilandDivision of Experimental Radiology, Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany.
Martin BendszusDepartment of Neuroradiology, Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.
Jennifer C HayesDepartment of Neuroradiology, Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany. jennifer.hayes@med.uni-heidelberg.de.ORCID http://orcid.org/0000-0002-6254-9192
Heidelberg University · DE

Funding

Deutsche Forschungsgemeinschaft SFB 1118Deutsche Forschungsgemeinschaft SFB 1158Medizinischen Fakultät Heidelberg, Universität Heidelberg Olympia MorataMedizinischen Fakultät Heidelberg, Universität Heidelberg Rahel Goetein-Straus
6 · The paper itself

Abstract

purposeRecent studies suggest an involvement of the peripheral nervous system (PNS) in multiple sclerosis (MS). Here, we characterize the proximal-to-distal distribution pattern of peripheral nerve lesions in relapsing-remitting MS (RRMS) by quantitative magnetic resonance neurography (MRN).

methodsA total of 35 patients with RRMS were prospectively included and underwent detailed neurologic and electrophysiologic examinations. Additionally, 30 age- and sex-matched healthy controls were recruited. 3T MRN with anatomical coverage from the proximal thigh down to the tibiotalar joint was conducted using dual-echo 2‑dimensional relaxometry sequences with spectral fat saturation. Quantification of PNS involvement was performed by evaluating microstructural (proton spin density (ρ), T2-relaxation time (T2

resultsIn patients with RRMS, tibial nerve lesions at the thigh and the lower leg were characterized by a decrease in T2

conclusionPNS involvement in RRMS is characterized by a decrease in T2

Indexed as

Multiple SclerosisMultiple Sclerosis, Relapsing-RemittingHumansMagnetic Resonance ImagingPeripheral NervesTibial NerveMagnetic resonance neurographyPeripheral nervous systemProton spin densityQuantitative imaging markersT2-relaxometry

Identifiers

PMID36264352
PMCPMC10219896
OpenAlexW4306910905

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.