Evidence map›Paper›PMID 36264101›Full record

ArticlemBio2022

RfaH Counter-Silences Inhibition of Transcript Elongation by H-NS-StpA Nucleoprotein Filaments in Pathogenic Escherichia coli.

Christine M Hustmyer, Michael B Wolfe, Rodney A Welch, Robert Landick

Open access · goldAbstract read
In one paragraph

Article in mBio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 17 citations in OpenAlex.

  1. RfaH licenses RNA polymerase for long-range transcription.bioRxiv : the preprint server for biology · 2026
    Article
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  13. One Earth: The Equilibrium between the Human and the Bacterial Worlds.International journal of molecular sciences · 2023
    Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Christine M HustmyerDepartment of Biochemistry, University of Wisconsin-Madisongrid.14003.36, Madison, Wisconsin, USA.ORCID 0000-0002-9144-3872
Michael B WolfeDepartment of Biochemistry, University of Wisconsin-Madisongrid.14003.36, Madison, Wisconsin, USA.ORCID 0000-0002-0276-0551
Rodney A WelchDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madisongrid.14003.36, Madison, Wisconsin, USA.
Robert LandickDepartment of Biochemistry, University of Wisconsin-Madisongrid.14003.36, Madison, Wisconsin, USA.ORCID 0000-0002-5042-0383
University of Wisconsin–Madison · US

Funding

STRUCTURE/FUNCTION OF TRANSCRIPTION COMPLEX RNA HAIRPINSR01GM038660 · NIGMS · WASHINGTON UNIVERSITY · PI Robert Landick · 1992 to 2026
$12.2M
Chemistry-Biology Interface Training ProgramT32GM008505 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BLACKWELL, HELEN E. · 1993 to 2023
$9.8M
NIGMS NIH HHS R01 GM038660NIGMS NIH HHS T32 GM008505
6 · The paper itself

Abstract

Expression of virulence genes in pathogenic Escherichia coli is controlled in part by the transcription silencer H-NS and its paralogs (e.g., StpA), which sequester DNA in multi-kb nucleoprotein filaments to inhibit transcription initiation, elongation, or both. Some activators counter-silence initiation by displacing H-NS from promoters, but how H-NS inhibition of elongation is overcome is not understood. In

Indexed as

Escherichia coliEscherichia coli ProteinsBacterial ProteinsDNADNA-Binding ProteinsDNA-Directed RNA PolymerasesMolecular ChaperonesNucleoproteinsPeptide Elongation FactorsTrans-ActivatorsTranscription FactorsTranscription, GeneticBacterial ProteinsDNADNA-Binding ProteinsDNA-Directed RNA PolymerasesEscherichia coli Proteinshns protein, E coliMolecular ChaperonesNucleoproteinsNusG protein, E coliPeptide Elongation FactorsRfaH protein, E coliStpA protein, E coliTrans-ActivatorsTranscription Factorsbacterial chromatinChIP-seqcounter-silencinggene silencingH-NSRNAPtranscript elongation

Identifiers

PMID36264101
PMCPMC9765446
OpenAlexW4306882845

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.