Evidence map›Paper›PMID 36263598›Full record

ArticleEpidemiology and psychiatric sciences2022

To what extent do social support and mastery mediate the association between childhood maltreatment and depression? A sequential causal mediation analysis.

Y Y Su, M Li, C D'Arcy, J Caron, K O'Donnell, X Meng

Abstract read
In one paragraph

Article in Epidemiology and psychiatric sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  12. Differential effects of lifetime stressors on major depressive disorder severity: a longitudinal community-based cohort study.European psychiatry : the journal of the Association of European Psychiatrists · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Y Y SuDepartment of Psychiatry, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC, Canada.ORCID https://orcid.org/0000-0002-5788-0593
M LiDepartment of Psychiatry, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC, Canada.
C D'ArcySchool of Public Health, University of Saskatchewan, Saskatoon, SK, Canada.
J CaronDepartment of Psychiatry, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC, Canada.
K O'DonnellDepartment of Psychiatry, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC, Canada.
X MengDepartment of Psychiatry, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC, Canada.ORCID https://orcid.org/0000-0002-0857-1305

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

aimsThis study aimed to examine the independent roles of various childhood maltreatment (CM) subtypes in the development of depression; quantify the joint mediation effect of social support and mastery in the association between subtypes of CM and depression and examine the additional contribution of mastery beyond the effect that is operating through social support to this relationship.

methodsData analysed were from the Zone d'Épidémiologie Psychiatrique du Sud-Ouest de Montréal, an ongoing longitudinal population-based study. In total, 1351 participants with complete information on the studied variables were included. The propensity score matching and inverse-probability weighted regression adjustment estimation methods were used to minimise the potential confounding in the relationship between CM and major depression. We then used inverse odds ratio-weighted estimation to estimate the direct effects of maltreatment and indirect effects of social support and mastery.

resultsWe found that exposures to all maltreatment subtypes increased the risk of subsequent depression. The joint mediating effect of social support and mastery explained 37.63-46.97% of the association between different maltreatment subtypes and depression. The contribution of these two mediators differed by maltreatment subtypes, with social support being the major contributor to the mediating effect.

conclusionsThe findings of the study not only provide scientific evidence on the importance of psychosocial attributes in the development of major depression but also suggest that prevention and invention strategies should focus on these psychosocial attributes to effectively break the vicious cycle of CM on major depression.

Indexed as

Child AbuseMajor Depressive DisorderChildDepressionHumansMediation AnalysisSocial SupportChildhood maltreatmentmajor depressionmasteryprospective studysocial support

Identifiers

PMID36263598
PMCPMC9677445

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.