ArticleActa psychiatrica Scandinavica2023
Depressive symptoms and mortality-findings from Helsinki birth cohort study.
Article in Acta psychiatrica Scandinavica, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 18 citations in OpenAlex.
- The non-linear association between depression scores and all-cause mortality: a cohort study based on NHANES 2005-2018 data.Scientific reports · 2025Article
- Association between physical activity and all-cause mortality in patients with depression: a prospective cohort study based on NHANES data.Frontiers in public health · 2025Article
- Mental and behavioral disorder mortality in Poland, 2000-2023: a national age-standardized Joinpoint regression study.Frontiers in public health · 2025Article
- Mortality in patients with major depressive disorder: A nationwide population-based cohort study with 11-year follow-up.European psychiatry : the journal of the Association of European Psychiatrists · 2024Article
- Association of both depressive symptoms scores and specific depressive symptoms with all-cause and cardiovascular disease mortality.Annals of general psychiatry · 2024Article
- Elevated Mortality Rate in Patients With Functional Seizures After Diagnosis and Referral.Neurology. Clinical practice · 2024Article
- Depressive symptoms and mortality-findings from Helsinki birth cohort study.Acta psychiatrica Scandinavica · 2023Article
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Authors and funding
11 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIndividuals with depression and depressive symptoms have a higher mortality rate than non-depressed individuals. The increased comorbidity and mortality associated with depression has remained largely unexplained. The underlying pathophysiological differences between depressive subtypes, melancholic and non-melancholic, may provide some explanation to this phenomenon.
methodsOne thousand nine hundred and ninety five participants (mean age 61 years) from the Helsinki Birth Cohort Study were recruited for this prospective study and followed up for a mean of 14.1 years. Information regarding medical history, lifestyle, and biochemical parameters were obtained. Depressive symptoms were assessed using the Beck Depression Inventory. Standardized mortality ratios were calculated.
resultsParticipants were followed up for a total of 28,044 person-years. The melancholic depressive group had an increased adjusted risk of mortality [HR 1.49 (95% CI: 1.02-2.20)] when compared to the non-depressive group. Comparing mortality to the whole population of Finland using standardized mortality ratios (SMR) both the non-melancholic [1.11 (95% CI: 0.85-1.44)] and melancholic depressive [1.26 (95% CI: 0.87-1.81)] groups had higher mortality than the non-depressive group [0.82 (95% CI: 0.73-0.93)].
conclusionsMelancholic depressive symptoms are most strongly related to a higher mortality risk.
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