Evidence map›Paper›PMID 36263427›Full record

ArticleFrontiers in genetics2022

Genome-wide analysis identified candidate variants and genes associated with heat stress adaptation in Egyptian sheep breeds.

Adel M Aboul-Naga, Alsamman M Alsamman, Achraf El Allali, Mohmed H Elshafie, Ehab S Abdelal, Tarek M Abdelkhalek, Taha H Abdelsabour, Layaly G Mohamed, Aladdin Hamwieh

Abstract read
In one paragraph

Article in Frontiers in genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Article
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  5. Mapping genomic adaptation to environmental heterogeneity in Indian native goat populations through landscape genomics.Mammalian genome : official journal of the International Mammalian Genome Society · 2026
    Article
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  7. Signature of Selection Analysis Reveals Candidate Genes Related to Climate Adaptation and Production Traits in Lao Native Goats.Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie · 2026
    Article
  8. Genomic insights into the recent evolution and biodiversity of Italian sheep breeds.Mammalian genome : official journal of the International Mammalian Genome Society · 2025
    Article
  9. Impacts of heat stress on growth performance and its mitigation in small ruminants.Animal frontiers : the review magazine of animal agriculture · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Adel M Aboul-NagaAnimal Production Research Institute, Agriculture Research Center (ARC), Cairo, Egypt.
Alsamman M AlsammanAgricultural Genetic Engineering Research Institute, Giza, Egypt.
Achraf El AllaliAfrican Genome Center, Mohammed VI Polytechnic University, Ben Guerir, Morocco.
Mohmed H ElshafieAnimal Production Research Institute, Agriculture Research Center (ARC), Cairo, Egypt.
Ehab S AbdelalAnimal Production Research Institute, Agriculture Research Center (ARC), Cairo, Egypt.
Tarek M AbdelkhalekAnimal Production Research Institute, Agriculture Research Center (ARC), Cairo, Egypt.
Taha H AbdelsabourAnimal Production Research Institute, Agriculture Research Center (ARC), Cairo, Egypt.
Layaly G MohamedAnimal Production Research Institute, Agriculture Research Center (ARC), Cairo, Egypt.
Aladdin HamwiehInternational Center For Agricultural Research in the Dry Areas (ICARDA), Giza, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heat stress caused by climatic changes is one of the most significant stresses on livestock in hot and dry areas. It has particularly adverse effects on the ability of the breed to maintain homeothermy. Developing countries are advised to protect and prepare their animal resources in the face of potential threats such as climate change. The current study was conducted in Egypt's three hot and dry agro-ecological zones. Three local sheep breeds (Saidi, Wahati, and Barki) were studied with a total of 206 ewes. The animals were exercised under natural heat stress. The heat tolerance index of the animals was calculated to identify animals with high and low heat tolerance based on their response to meteorological and physiological parameters. Genomic variation in these breeds was assessed using 64,756 single nucleotide polymorphic markers (SNPs). From the perspective of comparative adaptability to harsh conditions, our objective was to investigate the genomic structure that might control the adaptability of local sheep breeds to environmental stress under hot and dry conditions. In addition, indices of population structure and diversity of local breeds were examined. Measures of genetic diversity showed a significant influence of breed and location on populations. The standardized index of association (rbarD) ranged from 0.0012 (Dakhla) to 0.026 (Assuit), while for the breed, they ranged from 0.004 (Wahati) to 0.0103 (Saidi). The index of association analysis (I

Indexed as

dry areasEgyptGWASheat tolerancesheepSNP genotyping

Identifiers

PMID36263427
PMCPMC9574253

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.