ArticleFrontiers in neuroscience2022
Neurodynamic correlates for the cross-frequency coupled transcranial alternating current stimulation during working memory performance.
Article in Frontiers in neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Is transcranial alternating current stimulation effective for improving working memory? A three-level meta-analysis.Psychonomic bulletin & review · 2025Pooled it
- Deep learning-based electroencephalic decoding of the phase-lagged transcranial alternating current stimulation.Frontiers in human neuroscience · 2025Article
- Study on the effects of exercise intervention combined with virtual reality technology on emotions and brain networks in secondary school students with depressive symptoms.Frontiers in psychiatry · 2025Article
- Theta-gamma-coupling as predictor of working memory performance in young and elderly healthy people.Molecular brain · 2024Article
- Improving working memory by electrical stimulation and cross-frequency coupling.Molecular brain · 2024Article
- Neuromodulation of inhibitory control using phase-lagged transcranial alternating current stimulation.Journal of neuroengineering and rehabilitation · 2024Article
- No effects of the theta-frequency transcranial electrical stimulation for recall, attention control, and relation integration in working memory.Frontiers in human neuroscience · 2024Article
- Cross-Frequency Coupling and Intelligent Neuromodulation.Cyborg and bionic systems (Washington, D.C.) · 2023Review
- Resting-state electroencephalographic characteristics related to mild cognitive impairments.Frontiers in psychiatry · 2023Article
- Parametrizing alternating current stimulation for neuromodulation.Imaging neuroscience (Cambridge, Mass.)Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transcranial current stimulation is a neuromodulation technique used to modulate brain oscillations and, in turn, to enhance human cognitive function in a non-invasive manner. This study investigated whether cross-frequency coupled transcranial alternating current stimulation (CFC-tACS) improved working memory performance. Participants in both the tACS-treated and sham groups were instructed to perform a modified Sternberg task, where a combination of letters and digits was presented. Theta-phase/high-gamma-amplitude CFC-tACS was administered over electrode F3 and its four surrounding return electrodes (Fp1, Fz, F7, and C3) for 20 min. To identify neurophysiological correlates for the tACS-mediated enhancement of working memory performance, we analyzed EEG alpha and theta power, cross-frequency coupling, functional connectivity, and nodal efficiency during the retention period of the working memory task. We observed significantly reduced reaction times in the tACS-treated group, with suppressed treatment-mediated differences in frontal alpha power and unidirectional Fz-delta-phase to Oz-high-gamma-amplitude modulation during the second half of the retention period when network analyses revealed tACS-mediated fronto-occipital dissociative neurodynamics between alpha suppression and delta/theta enhancement. These findings indicate that tACS modulated top-down control and functional connectivity across the fronto-occipital regions, resulting in improved working memory performance. Our observations are indicative of the feasibility of enhancing cognitive performance by the CFC-formed tACS.
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