Evidence map›Paper›PMID 36263326›Full record

ReviewFrontiers in endocrinology2022

The role of oxidized lipid species in insulin resistance and NASH in children.

Nicola Santoro, Ariel E Feldstein

Erratum issuedOpen access · goldAbstract readReview
In one paragraph

Review in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Nicola SantoroDepartment of Pediatrics, Kansas Medical Center, Kansas City, KS, United States.
Ariel E FeldsteinDepartment of Pediatrics, University of California San Diego, La Jolla, CA, United States.
University of California, San Diego · USYale University · US

Funding

Pathogenesis of youth onset pre-diabetes and Type 2 diabetesR01DK111038 · NIDDK · YALE UNIVERSITY · PI CAPRIO, SONIA · 2016 to 2025
$7.0M
Using PCORnet to Expand the DS-CONNECT Cohort Through Healthcare System Recruitment, Incorporating Electronic Health Records, and Assessing Self-DeterminationU54HD090216 · NICHD · UNIVERSITY OF KANSAS LAWRENCE · PI COLOMBO, JOHN A. · 2016 to 2020
$6.2M
Sterile inflammation and pyroptotic cell death in liver fibrosisR01DK113592 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ariel Feldstein, HAROLD M HOFFMAN · 2017 to 2026
$4.8M
Pathophysiologic mechanisms leading to intrahepatic fat accumulation in obese youthR01MD015974 · NIMHD · YALE UNIVERSITY · PI SANTORO, NICOLA · 2021 to 2025
$3.3M
Hepatocyte-derived extracellular vesicles in alcoholic liver diseaseR01AA028134 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FELDSTEIN, ARIEL, TSUKAMOTO, HIDEKAZU · 2020 to 2024
$2.9M
Mechanisms of Obesity and Its Metabolic Complications in Youth.R01DK114504 · NIDDK · YALE UNIVERSITY · PI SANTORO, NICOLA · 2018 to 2022
$1.9M
NIAAA NIH HHS R01 AA028134NICHD NIH HHS U54 HD090216NIDDK NIH HHS R01 DK111038NIDDK NIH HHS R01 DK113592NIDDK NIH HHS R01 DK114504NIMHD NIH HHS R01 MD015974
6 · The paper itself

Abstract

During the last two decades, nonalcoholic fatty liver disease (NAFLD) has emerged as the most common hepatic disease in pediatrics, mainly owing to the rising prevalence of pediatric obesity. Epidemiological studies have shown that the progressive increase in NAFLD prevalence is associated not only with obesity but also with changes in dietary habits experienced by all age groups, characterized by the increased intake of added sugars and certain fatty acids. In this review article, we focus on the effect of oxidized fatty acids deriving from linoleic acid and arachidonic acid on the pathogenesis and progression of NAFLD in youth.

Indexed as

Insulin ResistanceNon-alcoholic Fatty Liver DiseaseAdolescentArachidonic AcidsChildFatty AcidsHumansLinoleic AcidsLipidsSugarsArachidonic AcidsFatty AcidsLinoleic AcidsLipidsSugarschildrendiabeteslipidsNAFLD (nonalcoholic fatty liver disease)PUFA (polyunsaturated fatty acids)

Identifiers

PMID36263326
PMCPMC9573982
OpenAlexW4300962070

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.