Evidence map›Paper›PMID 36263202›Full record

ArticleFrontiers in oncology2022

Clinically relevant dosing and pharmacokinetics of DNA-encoded antibody therapeutics in a sheep model.

Kevin Hollevoet, Debby Thomas, Griet Compernolle, Giles Vermeire, Elien De Smidt, Stéphanie De Vleeschauwer, Trevor R F Smith, Paul D Fisher, Maarten Dewilde, Nick Geukens and 1 more

Abstract read
In one paragraph

Article in Frontiers in oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. DNA-based delivery of G-CSF as a durable and efficacious approach to treat severe chronic neutropenia.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kevin HollevoetPharmAbs, The KU Leuven Antibody Center - University of Leuven, Leuven, Belgium.
Debby ThomasPharmAbs, The KU Leuven Antibody Center - University of Leuven, Leuven, Belgium.
Griet CompernollePharmAbs, The KU Leuven Antibody Center - University of Leuven, Leuven, Belgium.
Giles VermeireLaboratory for Therapeutic and Diagnostic Antibodies, KU Leuven - University of Leuven, Leuven, Belgium.
Elien De SmidtPharmAbs, The KU Leuven Antibody Center - University of Leuven, Leuven, Belgium.
Stéphanie De VleeschauwerLaboratory Animal Center, KU Leuven - University of Leuven, Leuven, Belgium.
Trevor R F SmithInovio Pharmaceuticals, San Diego, CA, United States.
Paul D FisherInovio Pharmaceuticals, San Diego, CA, United States.
Maarten DewildePharmAbs, The KU Leuven Antibody Center - University of Leuven, Leuven, Belgium.
Nick GeukensPharmAbs, The KU Leuven Antibody Center - University of Leuven, Leuven, Belgium.
Paul DeclerckPharmAbs, The KU Leuven Antibody Center - University of Leuven, Leuven, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

DNA-encoded delivery and

Indexed as

antibody gene transferelectroporationoncologyplasmid – gene deliverysheep

Identifiers

PMID36263202
PMCPMC9574358

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.