Evidence map›Paper›PMID 36263147›Full record

ArticleFrontiers in pediatrics2022

Differential effects of ibuprofen and indomethacin on cerebral oxygen kinetics in the very preterm baby.

Michael J Stark, Tara M Crawford, Nina M Ziegler, Anthea Hall, Chad C Andersen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Evaluation of the association between patent ductus arteriosus approach and neurodevelopment in extremely preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Michael J StarkDepartment of Neonatal Medicine, The Women's and Children's Hospital, North Adelaide, SA, Australia.
Tara M CrawfordRobinson Research Institute, School of Medicine, The University of Adelaide, Adelaide, SA, Australia.
Nina M ZieglerDepartment of Neonatal Medicine, The Women's and Children's Hospital, North Adelaide, SA, Australia.
Anthea HallRobinson Research Institute, School of Medicine, The University of Adelaide, Adelaide, SA, Australia.
Chad C AndersenDepartment of Neonatal Medicine, The Women's and Children's Hospital, North Adelaide, SA, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Ibuprofen is preferred to indomethacin for treatment of a significant patent ductus arteriosus (PDA) in preterm babies despite indomethacin being associated with a lower risk of intraventricular haemorrhage. This difference is thought to relate to the discrepant effects of each medication on cerebral oxygen kinetics yet the effect of ibuprofen on cerebral perfusion is uncertain. Methods: Forty-eight babies < 30 weeks with a significant PDA, defined by echocardiography, were randomly assigned to either indomethacin or ibuprofen ( Results: A fixed effect of time was seen for TICF ( Conclusion: Indomethacin significantly reduces cerebral blood flow soon after administration, resulting in a parallel increase in oxygen extraction and arterial lactate. This implies that the balance of oxygen kinetics at the time of treatment may be critical in very preterm babies with significant PDA.

Indexed as

fractional oxygen concentrationibuprofenindomethacinoxygen consumptionoxygen deliverypatent ductus arteriouspreterm neonate

Identifiers

PMID36263147
PMCPMC9574055

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.