Evidence map›Paper›PMID 36263052›Full record

ArticleFrontiers in immunology2022

The white blood cell count to mean platelet volume ratio for ischemic stroke patients after intravenous thrombolysis.

Yiyun Weng, Yufan Gao, Mingyue Zhao, Tian Zeng, Jiaqi Huang, Haobo Xie, Jiexi Huang, Yiqun Chen, Xiaoya Hu, Jiahan Xu and 5 more

Abstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yiyun WengDepartment of Neurology, Shandong Provincial Qianfoshan Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Yufan GaoDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Mingyue ZhaoDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Tian ZengDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Jiaqi HuangDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Haobo XieDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Jiexi HuangDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Yiqun ChenDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Xiaoya HuDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Jiahan XuDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Jinrong ZhuDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Suichai LinDepartment of Emergency, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Tingting KeDepartment of Emergency, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Xiang LiDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Xu ZhangDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Purpose: White blood cell count to mean platelet volume ratio (WMR) is increasingly recognized as a promising biomarker. However, its predictive capability for acute ischemic stroke (AIS) patients is relatively less researched. The primary aim of this study is to explore its prognostic value in AIS patients after reperfusion regarding 3-month poor functional outcome. Methods: A total of 549 AIS patients who had undergone vascular reperfusion procedure with complete 3-month follow-up were retrospectively recruited in this study. White blood cell count, mean platelet volume at 24 h of admission were recorded. Stroke severity had been estimated using the National Institutes of Health Stroke Scale (NIHSS) and poor outcome was defined as modified Rankin Scale (mRS) 3-6 at 3 months. Results: AIS patients with poor functional outcome at 3 months displayed higher WMR. A positive correlation between WMR and NIHSS score was found (r = 0.334, Conclusions: WMR is significantly correlated with stroke severity on admission and is proved to be an important prognostic indicator for AIS outcomes, especially in high NIHSS on admission group. Additionally, the developed nomogram that includes high WMR for predicting 1-year survival provides us with an effective visualization tool.

Indexed as

Brain IschemiaIschemic StrokeStrokeBiomarkersHumansLeukocyte CountMean Platelet VolumeRetrospective StudiesThrombolytic TherapyUnited StatesBiomarkersinflammationintravenous thrombolysisischemic strokeprognosisWMR

Identifiers

PMID36263052
PMCPMC9574706

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.