Evidence map›Paper›PMID 36263044›Full record

ArticleFrontiers in immunology2022

T-cell deficiency and hyperinflammatory monocyte responses associate with

Cecilia S Lindestam Arlehamn, Basilin Benson, Rebecca Kuan, Kimberly A Dill-McFarland, Glenna J Peterson, Sinu Paul, Felicia K Nguyen, Robert H Gilman, Mayuko Saito, Randy Taplitz and 7 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07363798 (Association of Nutrition and T Cell Immune Activity With Disease Progression in Nontuberculous Mycobacterial Pulmonary Disease), which is not on this map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07363798 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Association of Nutrition and T Cell Immune Activity With Disease Progression in Nontuberculous Mycobacterial Pulmonary Disease

Typeobservational_patient_registrySponsorSeoul National University HospitalRan2026 to 2027Enrolled50ConditionsNontuberculous Mycobacterial Pulmonary Disease, Nontuberculous Mycobacterial Lung Disease
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 18 citations in OpenAlex.

  1. Blood transcriptomic signatures distinguishEmerging microbes & infections · 2026
    Article
  2. Article
  3. Immunodominant Tuberculosis Antigens Recognized by Human CD4Cold Spring Harbor perspectives in medicine · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. An alveolus lung-on-a-chip model ofbioRxiv : the preprint server for biology · 2025
    Article
  8. Article
  9. Review
  10. Assays for AssessingPathogens (Basel, Switzerland) · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Swollen Necrotic Lymphadenitis Infected withInfection and drug resistance · 2024
    Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 4 countries.

Cecilia S Lindestam ArlehamnCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, United States.
Basilin BensonDepartment of Medicine, University of Washington, Seattle, WA, United States.
Rebecca KuanCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, United States.
Kimberly A Dill-McFarlandDepartment of Medicine, University of Washington, Seattle, WA, United States.
Glenna J PetersonDepartment of Medicine, University of Washington, Seattle, WA, United States.
Sinu PaulCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, United States.
Felicia K NguyenDepartment of Medicine, University of Washington, Seattle, WA, United States.
Robert H GilmanJohns Hopkins University, Bloomberg School of Public Health, Baltimore, MD, United States.
Mayuko SaitoDepartment of Virology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Randy TaplitzDepartment of Medicine, City of Hope National Medical Center, Duarte, CA, United States.
Matthew ArentzDepartment of Global Health, University of Washington, Seattle, WA, United States.
Christopher H GossDepartment of Medicine, University of Washington, Seattle, WA, United States.
Moira L AitkenDepartment of Medicine, University of Washington, Seattle, WA, United States.
David J HorneDepartment of Medicine, University of Washington, Seattle, WA, United States.
Javeed A ShahDepartment of Medicine, University of Washington, Seattle, WA, United States.
Alessandro SetteCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, United States.
Thomas R HawnDepartment of Medicine, University of Washington, Seattle, WA, United States.
University of Washington · USLa Jolla Institute for Immunology · USCity Of Hope National Medical Center · USFoundation for Innovative New Diagnostics · CHTohoku University · JPUniversidad Peruana Cayetano Heredia · PEUniversity of California, San Diego · US

Funding

Institute of Translational Health SciencesUL1TR000423 · NCATS · UNIVERSITY OF WASHINGTON · PI DISIS, MARY L. · 2012 to 2016
$49.4M
Translational Research Center to Expedite Novel Therapies in Cystic FibrosisP30DK089507 · NIDDK · SEATTLE CHILDREN'S HOSPITAL · PI Christopher Hooper Goss · 2010 to 2026
$21.4M
A Phase 1b, Multi-center Study of IV Gallium Nitrate in Patients with Cystic Fibrosis who are colonized with Nontuberculosis Mycobacterium (The ABATE Study).R01FD006848 · FDA · SEATTLE CHILDREN'S HOSPITAL · PI Christopher Hooper Goss, JERRY A NICK · 2020 to 2026
$3.1M
Pulmonary Innate Immunity & Resistance to Mycobacterium Tuberculosis InfectionK24AI137310 · NIAID · UNIVERSITY OF WASHINGTON · PI HAWN, THOMAS R · 2018 to 2022
$892k
Illumina HiSeq 2500 Sequencing SystemS10OD016262 · OD · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI RAO, ANJANA · 2013 to 2013
$600k
FACSAria II Cell SorterS10RR027366 · NCRR · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI CROFT, MICHAEL · 2011 to 2011
$514k
Non-tuberculous Mycobacteria & Heterologous ImmunityR21AI125777 · NIAID · UNIVERSITY OF WASHINGTON · PI HAWN, THOMAS R, SETTE, ALESSANDRO · 2018 to 2019
$509k
FDA HHS R01 FD006848NCATS NIH HHS UL1 TR000423NCRR NIH HHS S10 RR027366NIAID NIH HHS K24 AI137310NIAID NIH HHS R21 AI125777NIDDK NIH HHS P30 DK089507NIH HHS S10 OD016262
6 · The paper itself

Abstract

Immunological mechanisms of susceptibility to nontuberculous mycobacterial (NTM) disease are poorly understood. To understand NTM pathogenesis, we evaluated innate and antigen-specific adaptive immune responses to

Indexed as

Lung DiseasesMycobacterium avium-intracellulare InfectionCytokinesHumansImmunologic Deficiency SyndromesMonocytesMycobacterium avium ComplexThymus GlandT-LymphocytesCytokinesimmune responseMAC pathogenesismycobacterium avium complex (MAC)NTM = nontuberculous mycobacteriaT cells

Identifiers

PMID36263044
PMCPMC9574438
OpenAlexW4300960648

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.