ArticleBioMed research international2022
PRP from Personal Blood Relieves Joint Fluid-Inducing Synovial Injury through NF-
Article in BioMed research international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Retracted: PRP from Personal Blood Relieves Joint Fluid-Inducing Synovial Injury through NF-BioMed research international · 2023Article
Corrections and comments
- Retraction · 2023-08-02Concerns/Issues about Data · Concerns/Issues about Human Subject Welfare · Concerns/Issues about Referencing/Attributions · Concerns/Issues about Peer Review · Investigation by Journal/Publisher · Investigation by Third Party · Lack of IRB/IACUC Approval and/or Compliance · Unreliable Results and/or Conclusions ·
- Retracted
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Platelet-rich plasma (PRP) therapy is a new kind of biological therapy to retune the plasma concentrator into the patient's body for the treatment of osteoarthritis diseases. The present research aimsed to confirm the treatment effects of PRP against osteoarthritis injury and elucidate its potential mechanism via constructing a kind of cellular injury model of human synovial fibroblast cells (HSF cells) induced by synovial fluid from osteoarthritis patients. Materials and Methods: HSF cells wereas firstly treated with the different doses of synovial fluid from osteoarthritis patients, and evaluated for the cellular injury via cell morphology and MTT assay. And then, the protective effect of PRP against cellular injury were examined by cell morphology and MTT assay. Following, flow cytometry and western blot assay were employed to evaluate the effect of PRP on mitochondrial apoptosis. Finally, the effect of PRP on NF- Results: The dilution ratio 1 : 5 of synovial fluid displayed an excellent injury effect against HSF cells and selected as the model condition. The data from cellular image and MTT assay showed that PRP with the doses 1 : 5 and 1 : 10 could alleviate the cellular mounts decrease in the damaged HSF cells. Flow cytometry, western blot, and Elisa ELISA assay displayed that PRP could relieve the cellular mitochondrial apoptosis and NF- Conclusion: PRP might relieve HSF cells injury induced by synovial fluid from osteoarthritis patients through alleviating the mitochondrial apoptosis and NF-
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Registered trials
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