Evidence map›Paper›PMID 36262897›Full record

ArticleJournal of community hospital internal medicine perspectives2022

A Case of Adult Multisystem Inflammatory Syndrome Following COVID-19 Vaccine.

Meghan Brown, Nika Z Garbajs, Simon Zec, Hisham Mushtaq, Anwar Khedr, Abbas B Jama, Ibtisam Rauf, Mikael Mir, Aishwarya R Korsapati, Shikha Jain and 10 more

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of community hospital internal medicine perspectives, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 9 institutions in 4 countries.

Meghan BrownMayo Clinic, Rochester, MN, USA.
Nika Z GarbajsMayo Clinic, Rochester, MN, USA.
Simon ZecMayo Clinic, Rochester, MN, USA.
Hisham MushtaqMayo Clinic Health System, Mankato, USA.
Anwar KhedrMayo Clinic Health System, Mankato, USA.
Abbas B JamaMayo Clinic Health System, Mankato, USA.
Ibtisam RaufSt George's University, True Blue, Grenada.
Mikael MirUniversity of Minnesota, Duluth, MN, USA.
Aishwarya R KorsapatiUniversity of Buckingham Medical School, London, United Kingdom.
Shikha JainMVJ Medical College and Research Hospital, Bengaluru, India.
Thoyaja KoritalaMayo Clinic Health System, Mankato, USA.
Ramesh AdhikariFranciscan Health Lafayette East, Lafayette, IN, USA.
Amos LalMayo Clinic, Rochester, MN, USA.
Ognjen GajicMayo Clinic, Rochester, MN, USA.
Juan Pablo DomecqMayo Clinic, Rochester, MN, USA.
Sarah GoksoyUniversity of California, Berkeley, CA, USA.
Brian BartlettMayo Clinic Health System, Mankato, USA.
Amit SharmaGeisinger Community Medical Center, Scranton, PA, USA.
Nitesh Kumar JainMayo Clinic Health System, Mankato, USA.
Syed Anjum KhanMayo Clinic Health System, Mankato, USA.
Mayo Clinic Health System · USMayo Clinic in Arizona · USCommunity Medical Center · USFranciscan Health · USMVJ Medical College and Research Hospital · INSt. George's University · GDUniversity of Buckingham · GBUniversity of California, Berkeley · USUniversity of Minnesota, Duluth · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multisystem inflammatory syndrome is a life-threatening condition associated with elevated inflammatory markers and multiple organ injury. A diagnosis of exclusion, it has been reported after severe acute respiratory syndrome coronavirus 2 infection (SARS-CoV-2) in children and adults; recently it has been described in some post-COVID-19 vaccinated individuals. The prognosis with supportive care and immunomodulatory therapy is good, although some individuals may require treatment in the intensive care unit (ICU). Here we report a case of a 58-year-old man who developed multi-organ failure after receiving the second dose of the Moderna mRNA-1273 COVID-19 vaccine. He required critical organ support in the ICU. An extensive workup was done to rule out alternative infectious and inflammatory processes. Following a period of gradual in-hospital convalescence, our patient made a full recovery. To our knowledge, this is the first comprehensively described case of multisystem inflammatory syndrome associated with Moderna mRNA-1273 COVID-19 vaccine in an adult over 50 years of age.

Indexed as

Acute tubular necrosis (ATN)COVID-19 vaccineImmunological products and vaccinesIntensive careMultisystem inflammatory syndrome in adults (MIS-A)Multisystem inflammatory syndrome in vaccinated individuals (MIS-V)Unwanted effects/Adverse reactionsVaccination/immunization

Identifiers

PMID36262897
PMCPMC9533789
OpenAlexW4284962209

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.