Evidence map›Paper›PMID 36262875›Full record

ArticlePathology oncology research : POR2022

Pomalidomide Treatment in Relapsed/Refractory Multiple Myeloma Patients-Real-World Data From Hungary.

Szilvia Lovas, Nóra Obajed Al-Ali, Gergely Varga, Virág Szita, Hussain Alizadeh, Márk Plander, Péter Rajnics, Árpád Illés, Zsuzsa Szemlaky, Gábor Mikala and 1 more

Abstract read
In one paragraph

Article in Pathology oncology research : POR, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Szilvia LovasDepartment of Hematology, Institute for Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Nóra Obajed Al-AliDepartment of Hematology, Institute for Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Gergely VargaDepartment of Internal Medicine and Hematology, Semmelweis University, Budapest, Hungary.
Virág SzitaDepartment of Internal Medicine and Hematology, Semmelweis University, Budapest, Hungary.
Hussain Alizadeh1st Department of Internal Medicine, University of Pécs, Pécs, Hungary.
Márk PlanderDepartment of Hematology, Markusovszky Teaching Hospital, Szombathely, Hungary.
Péter RajnicsDepartment of Hematology, Mór Kaposi Teaching Hospital, Kaposvár, Hungary.
Árpád IllésDepartment of Hematology, Institute for Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Zsuzsa SzemlakyDepartment of Hematology and Stem Cell Transplantation, South-Pest Central Hospital, National Institute for Hematology and Infectious Diseases, Budapest, Hungary.
Gábor MikalaDepartment of Hematology and Stem Cell Transplantation, South-Pest Central Hospital, National Institute for Hematology and Infectious Diseases, Budapest, Hungary.
László VáróczyDepartment of Hematology, Institute for Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pomalidomide is a third generation immunomodulatory drug in the treatment of refractory and relapsed multiple myeloma patients. Our aim was to investigate the efficacy and safety of pomalidomide therapy in a real world setting. Eighty-six Hungarian patients were included, 45 of whom received pomalidomide ± an alkylating agent, while in 38 of them pomalidomide was combined with a proteasome inhibitor. 56 patients (65%) showed any response to the treatment with 18 complete or very good partial remissions and 38 partial remissions. At a median duration of follow-up of 18.6 months, the median progression-free survival (PFS) was 9.03 months, while the median overall survival (OS) was 16.53 months in the whole cohort. Patients with early stage disease (R-ISS 1 and 2) had better survival results than those with stage 3 myeloma (

Indexed as

Multiple MyelomaAlkylating AgentsAntineoplastic Combined Chemotherapy ProtocolsDexamethasoneHumansHungaryLenalidomideProteasome InhibitorsThalidomideTreatment OutcomeAlkylating AgentsDexamethasoneLenalidomidepomalidomideProteasome InhibitorsThalidomidemultiple myelomapomalidomidesurvivaltoxicitytreatment response

Identifiers

PMID36262875
PMCPMC9573944

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.