Evidence map›Paper›PMID 36262667›Full record

ArticleJID innovations : skin science from molecules to population health2022

Ninjurin1 Deletion in NG2-Positive Pericytes Prevents Microvessel Maturation and Delays Wound Healing.

Risa Matsuo, Mari Kishibe, Kiwamu Horiuchi, Kohei Kano, Takamitsu Tatsukawa, Taiki Hayasaka, Maki Kabara, Shin Iinuma, Ryoji Eguchi, Satomi Igawa and 3 more

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In one paragraph

Article in JID innovations : skin science from molecules to population health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Risa MatsuoDepartment of Biochemistry, Asahikawa Medical University, Asahikawa, Japan.
Mari KishibeDepartment of Dermatology, Asahikawa Medical University, Asahikawa, Japan.
Kiwamu HoriuchiDepartment of Biochemistry, Asahikawa Medical University, Asahikawa, Japan.
Kohei KanoDepartment of Biochemistry, Asahikawa Medical University, Asahikawa, Japan.
Takamitsu TatsukawaDepartment of Biochemistry, Asahikawa Medical University, Asahikawa, Japan.
Taiki HayasakaDepartment of Biochemistry, Asahikawa Medical University, Asahikawa, Japan.
Maki KabaraDepartment of Biochemistry, Asahikawa Medical University, Asahikawa, Japan.
Shin IinumaDepartment of Dermatology, Asahikawa Medical University, Asahikawa, Japan.
Ryoji EguchiDepartment of Biochemistry, Asahikawa Medical University, Asahikawa, Japan.
Satomi IgawaDepartment of Dermatology, Asahikawa Medical University, Asahikawa, Japan.
Naoyuki HasebeDivision of Cardiovascular, Respiratory and Neurology, Department of Medicine, Asahikawa Medical University, Asahikawa, Japan.
Akemi Ishida-YamamotoDepartment of Dermatology, Asahikawa Medical University, Asahikawa, Japan.
Jun-Ichi KawabeDepartment of Biochemistry, Asahikawa Medical University, Asahikawa, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The formation of mature vasculature through angiogenesis is essential for adequate wound healing, such that blood-borne cells, nutrients, and oxygen can be delivered to the remodeling skin area. Neovessel maturation is highly dependent on the coordinated functions of vascular endothelial cells and perivascular cells, namely pericytes (PCs). However, the underlying mechanism for vascular maturation has not been completely elucidated, and its role in wound healing remains unclear. In this study, we investigated the role of Ninjurin-1 (Ninj1), a new molecule mediating vascular maturation, in wound healing using an inducible PC-specific

Indexed as

3D, three-dimensionalEC, endothelial cellKC, keratinocyteKO, knockoutNinj1, Ninjurin-1PC, pericyteTam, tamoxifenVSMC, vascular smooth muscle cellWT, wild-type

Identifiers

PMID36262667
PMCPMC9573932

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.