Evidence map›Paper›PMID 36262398›Full record

ArticleACS medicinal chemistry letters2022

Radiolabeled Aminopyrazoles as Novel Isoform Selective Probes for pJNK3 Quantification.

Brian C Bales, Victoria Cotero, Dan E Meyer, Jeannette C Roberts, Monica Rodriguez-Silva, Tiberiu M Siclovan, Jeremy W Chambers, Michael J Rishel

Open access · greenAbstract read
In one paragraph

Article in ACS medicinal chemistry letters, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Brian C BalesDepartment of Biology and Applied Physics, GE Research, One Research Circle, Niskayuna, New York 12309, United States.
Victoria CoteroDepartment of Biology and Applied Physics, GE Research, One Research Circle, Niskayuna, New York 12309, United States.
Dan E MeyerDepartment of Biology and Applied Physics, GE Research, One Research Circle, Niskayuna, New York 12309, United States.
Jeannette C RobertsDepartment of Biology and Applied Physics, GE Research, One Research Circle, Niskayuna, New York 12309, United States.
Monica Rodriguez-SilvaDepartment of Environmental Health Sciences, Robert Stempel College of Public Health & Social Work, Florida International University, Miami, Florida 33199, United States.
Tiberiu M SiclovanDepartment of Biology and Applied Physics, GE Research, One Research Circle, Niskayuna, New York 12309, United States.
Jeremy W ChambersDepartment of Environmental Health Sciences, Robert Stempel College of Public Health & Social Work, Florida International University, Miami, Florida 33199, United States.
Michael J RishelDepartment of Biology and Applied Physics, GE Research, One Research Circle, Niskayuna, New York 12309, United States.ORCID https://orcid.org/0000-0002-5191-6313
GE Global Research (United States) · USFlorida International University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The c-Jun N-terminal kinase 3 (JNK3) is a stress-activated kinase primarily expressed in the brain and implicated as an early mediator of neuronal apoptosis. We sought to develop a PET tracer to visualize pathological JNK3 activation. Because regional JNK3 activation precedes apoptosis, such an imaging agent might enable the detection of "at risk" brain regions prior to neuronal death. We prepared a set of

Identifiers

PMID36262398
PMCPMC9575163
OpenAlexW4297497825

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.