Evidence map›Paper›PMID 36262323›Full record

ArticleFrontiers in microbiology2022

A therapeutic chimeric IgG/IgA expressed by CHO cells for oral treatment of PED in piglets.

Yan Xiao, Yunjing Zhang, Zhiyan Wang, Wenyin Zhao, Xin Xu, Xiao Chen, Feifei Tan, Zhe Sun, Baicheng Huang, Kegong Tian

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yan XiaoCollege of Veterinary Medicine, Henan Agricultural University, Zhengzhou, Henan, China.
Yunjing ZhangNational Research Center for Veterinary Medicine, Luoyang, Henan, China.
Zhiyan WangNational Research Center for Veterinary Medicine, Luoyang, Henan, China.
Wenyin ZhaoNational Research Center for Veterinary Medicine, Luoyang, Henan, China.
Xin XuNational Research Center for Veterinary Medicine, Luoyang, Henan, China.
Xiao ChenNational Research Center for Veterinary Medicine, Luoyang, Henan, China.
Feifei TanNational Research Center for Veterinary Medicine, Luoyang, Henan, China.
Zhe SunNational Research Center for Veterinary Medicine, Luoyang, Henan, China.
Baicheng HuangResearch Center for Intelligent Computing Platforms, Zhejiang Laboratory, Hangzhou, China.
Kegong TianCollege of Veterinary Medicine, Henan Agricultural University, Zhengzhou, Henan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immunoglobulin A (IgA) of sows is critically important for assessing piglets' protective capacity against porcine epidemic diarrhea virus (PEDV). Here, we report a therapeutic chimeric anti-PEDV IgG/IgA expressed by Chinese hamster ovary (CHO) cells for oral treatment of PED. The chimeric anti-PEDV IgG/IgA was produced by the CHO cell lines, in which the heavy chain was constructed by combining the VH, Cγ1 and hinge regions of PEDV IgG mAb 8A3, and the Cα2 and Cα3 domains of a Mus musculus immunoglobulin alpha chain. The chimeric anti-PEDV IgG/IgA could neutralize the strains of CV777 (G1), P014 (G2) and HN1303 (G2)

Indexed as

cell lineChinese hamster ovary cellimmunoglobulin Aoral treatmentporcine epidemic diarrhea virus

Identifiers

PMID36262323
PMCPMC9574063

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.