ArticleInternational journal of heart failure2022
Left Atrial Dysfunction, Fibrosis and the Risk of Thromboembolism in Patients With Paroxysmal and Persistent Atrial Fibrillation.
Article in International journal of heart failure, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Systolic Blood Pressure Variability and Outcomes in Atrial Fibrillation: A Nationwide Population Study in Korea.Journal of Korean medical science · 2026Article
- Reassessing the need for long-term oral anticoagulation following successful atrial fibrillation ablation: a systematic review and meta-analysis.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026Review
- Age-Dependent Role of Genetics and Renal Function for Atrial Fibrillation Development in Hypertrophic Cardiomyopathy.Korean circulation journal · 2025Article
- Real-World Observations in Patients With Obstructive Hypertrophic Cardiomyopathy Treated With Mavacamten: Evidence of Favorable Disease Modification.Journal of the American Heart Association · 2025Observational
- The risk factors of atrial substrate remodeling in the patients of paroxysmal atrial fibrillation following pulmonary vein isolation.BMC cardiovascular disorders · 2025Article
- Risk factors and nomogram prediction model for recurrence after radiofrequency ablation in patients with persistent atrial fibrillation.BMC cardiovascular disorders · 2025Article
- Association between left atrial function and pulmonary vein stump thrombus after left upper lobectomy: insights from cine-MRI.Scientific reports · 2025Article
- Does Spontaneous Echo Contrast in the Left Atrial Appendage Increase Thromboembolism Risk After Left Atrial Appendage Closure? A Retrospective Study on Its Impact on Device-Related Thrombosis and Arterial Thromboembolic Events.Cardiovascular therapeutics · 2025Article
- Clinical impacts of concomitant left atrial appendage occlusion during mitral valve surgery in patients with mitral regurgitation.Scientific reports · 2024Article
- Development and validation of a nomogram superior to CHADSJournal of thoracic disease · 2024Article
- What Is the Right Direction for theInternational journal of heart failure · 2024Article
- Effects of septal myectomy on left atrial and left ventricular function in obstructive hypertrophic cardiomyopathy.ESC heart failure · 2023Article
- Multimodality Imaging in Patients with Hypertrophic Cardiomyopathy and Atrial Fibrillation.Diagnostics (Basel, Switzerland) · 2023Review
- Role of cardiac imaging in management of heart failure.The Korean journal of internal medicine · 2023Review
- Optimization of guideline-directed medical treatment for heart failure patients with reduced ejection fraction.The Korean journal of internal medicine · 2023Review
- Left Atrial Remodeling and Thromboembolic Risk in Patients With Atrial Fibrillation.International journal of heart failure · 2022Article
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8 authors.
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Abstract
Background and Objectives: Left atrial (LA) fibrosis is an important component of the arrhythmogenic substrate and is related to LA dysfunction in patients with atrial fibrillation (AF). However, its relationship with functional changes and the risk of thrombus in patients with paroxysmal AF (PAF) and persistent AF (PeAF) remains unclear. Methods: We included 139 patients with preprocedural cardiac magnetic resonance imaging (CMR) and transesophageal echocardiography (TEE) for the first AF catheter ablation. Spontaneous echo contrast (SEC) and multiple parameters of LA were measured from TEE and CMR. LA fibrosis was evaluated by late gadolinium enhancement of LA (LA-LGE) of CMR. Results: The presence of SEC was higher in patients with PeAF than in patients with PAF (26.4% vs. 11.9%, p=0.03). The patients with SEC had more enlarged LA size and impaired function of LA and LAA, regardless of AF type. However, the area of LA-LGE was more extensive in patients with SEC in PeAF (27.5±15.9 vs. 20.1±10.3, p=0.033), not in PAF. In PAF, maximal LA volume index was closely related to the presence of SEC with marginal trend toward significance (odd ratio [OR], 1.07; 95% confidence interval [CI], 0.99-1.16; p=0.072). Whereas, a larger area of LA-LGE and lower emptying flux of LA appendage were independently related with SEC (OR, 1.10; 95% CI, 1.0-1.20; p=0.049 and OR, 0.93; 95% CI, 0.86-0.99; p=0.022, respectively) after adjusting related cardiovascular risk factors of SEC. Conclusions: In this study, we suggest that the risk of thrombus is provoked by LA enlargement with dysfunction in early-stage AF and by stiffened LA with fibrosis rather than LA size when it becomes PeAF.
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