ArticleEnvironmental analysis, health and toxicology2022
Impact of polystyrene microplastic exposure on lipid profile and oxidative stress status of male and female Wistar rats.
Article in Environmental analysis, health and toxicology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 32 citations in OpenAlex.
- Dose-Dependent Toxicological Effects of Polyvinyl Chloride and Polystyrene Microplastics on Wistar Albino Rats.Journal of applied toxicology : JAT · 2026Article
- Polystyrene Microplastics Induce Sustained Cardiovascular Redox Imbalance and Alter Mitochondrial Quality Control.Antioxidants (Basel, Switzerland) · 2026Article
- Micro-nanoplastic induced cardiovascular disease and dysfunction: a scoping review.Journal of exposure science & environmental epidemiology · 2025Article
- Oral Exposure to Nylon-11 and Polystyrene Nanoplastics During Early-Life in Rats.Nanomaterials (Basel, Switzerland) · 2025Article
- Cardiotoxicity of Microplastics: An Emerging Cardiovascular Risk Factor.Current cardiology reviews · 2025Review
- Microplastics exposure altered hematological and lipid profiles as well as liver and kidney function parameters in albino rats (Rattus norvegicus).Environmental analysis, health and toxicology · 2024Article
- An Emerging Role of Micro- and Nanoplastics in Vascular Diseases.Life (Basel, Switzerland) · 2024Review
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microplastics (MPs) are currently global environmental pollutants, and their associated health risks cannot be ignored. However, research on MP toxicity in mammals is limited. We investigated the effects of polystyrene microplastic (PS-MP) particles on the lipid profile and oxidative stress markers of Wistar rats. Two forms of PS-MP-pristine polystyrene and Styrofoam microplastics-particles of diameter <5 mm were used in this study. Each form was separately incorporated into rat feed in varying proportions of 1, 5 and 10%. A total of seventy rats (thirty-five male and thirty-five female rats) were used for this study and were separately distributed into seven groups of five rats each. The rats were then randomly assigned to a control group which received normal rat feed and water and six (6) test groups which were fed varying percentages (1, 5 and 10) of polystyrene microplastics diet for a period of 90 days. The rats were sacrificed under mild diethyl ether anesthesia 12 hr after cessation of treatment and blood was collected for lipid profile and oxidative stress analyses. Results obtained showed that oral exposure to microplastics caused decreased high density lipoprotein cholesterol (HDL-C) and increased low density lipoprotein cholesterol (LDL-C) in the rats. In contrast, there were no significant changes in oxidative stress parameters in the rats following microplastics exposure. Atherogenic indices in the PS-MP exposed rats differed according to gender. These results indicated that PS-MP dietary exposure may lead to dyslipidemia and male rats had higher cardiovascular risk.
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