Evidence map›Paper›PMID 36261843›Full record

ArticleNutrition & metabolism2022

Dietary protein and the glycemic index handle insulin resistance within a nutritional program for avoiding weight regain after energy-restricted induced weight loss.

Fernando Vidal-Ostos, Omar Ramos-Lopez, Susan A Jebb, Angeliki Papadaki, Andreas F H Pfeiffer, Teodora Handjieva-Darlenska, Marie Kunešová, Ellen E Blaak, Arne Astrup, J Alfredo Martinez and 1 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrition & metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00390637 (Diet, Obesity and Genes), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00390637 phase4completednot on this map

Diet, Obesity and Genes

TypeinterventionalSponsorUniversity of CopenhagenRan2006 to 2009Enrolled1,020ConditionsObesity, Metabolic Syndrome, Type 2 Diabetes, Cardiovascular DiseaseArmsHigh or low Glycemic Index and high or low Protein Diet
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 9 institutions in 8 countries.

Fernando Vidal-OstosEscuela Internacional de Doctorado de la UNED, Bravo Murillo 39, Madrid, Spain.
Omar Ramos-LopezMedicine and Psychology School, Autonomous University of Baja California, Universidad 14418, UABC, Parque Internacional Industrial Tijuana, 22390, Tijuana, B.C., Mexico. oscar.omar.ramos.lopez@uabc.edu.mx.
Susan A JebbNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
Angeliki PapadakiCentre for Exercise, Nutrition and Health Sciences, School for Policy Studies, University of Bristol, Bristol, UK.
Andreas F H PfeifferDepartment of Endocrinology, Diabetes and Nutrition, Charité Universitätsmedizin Berlin, German Center of Diabetes Research, DZD, Berlin, Germany.
Teodora Handjieva-DarlenskaDepartment of Pharmacology and Toxicology, Faculty of Medicine, Medical University, Sofia, Bulgaria.
Marie KunešováObesity Management Centre, Institute of Endocrinology, Prague, Czech Republic.
Ellen E BlaakDepartment of Human Biology, NUTRIM, School for Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands.
Arne AstrupObesity and Nutrition Science, Novo Nordisk Fonden, Tuborg Havnevej 15, 2900, Hellerup, Denmark.
J Alfredo MartinezNavarra's Health Research Institute (IdiSNA), Pamplona, Spain.
Diet, Obesity, and Genes (Diogenes) Project
German Center for Diabetes Research · DEInstitute of Endocrinology · CZMaastricht University · NLMadrid Institute for Advanced Studies · ESMedical University of Sofia · BGNovo Nordisk Foundation · DKUniversidad Autónoma de Baja California · MXUniversity of Bristol · GBUniversity of Oxford · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimThe role of dietary protein and glycemic index on insulin resistance (based on TyG index) within a nutritional program for weight loss and weight maintenance was examined.

methodsThis study analyzed 744 adults with overweight/obesity within the DIOGenes project. Patients who lost at least 8% of their initial weight (0-8 weeks) after a low-calorie diet (LCD) were randomly assigned to one of five ad libitum diets designed for weight maintenance (8-34 weeks): high/low protein (HP/LP) and high/low glycemic index (HGI/LGI), plus a control. The complete nutritional program (0-34 weeks) included both LCD plus the randomized diets intervention. The TyG index was tested as marker of body mass composition and insulin resistance.

resultsIn comparison with the LP/HGI diet, the HP/LGI diet induced a greater BMI loss (p < 0.05). ∆TyG was positively associated with resistance to BMI loss (β = 0.343, p = 0.042) during the weight maintenance stage. In patients who followed the HP/LGI diet, TyG (after LCD) correlated with greater BMI loss in the 8-34 weeks period (r = -0.256; p < 0.05) and during the 0-34 weeks intervention (r = -0.222, p < 0.05) periods. ΔTyG

conclusionsA HP/LGI diet is beneficial not only for weight maintenance after a LCD, but is also related to IR amelioration as assessed by TyG index changes. Registration Clinical Trials NCT00390637.

Indexed as

Glycemic indexInsulin resistanceMetabolic improvementPrecision nutritionProtein dietTyG index

Identifiers

PMID36261843
PMCPMC9583584
OpenAlexW4306810318

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.