Evidence map›Paper›PMID 36261826›Full record

ArticleBMC medical ethics2022

Patients' views on using human embryonic stem cells to treat Parkinson's disease: an interview study.

Jennifer Drevin, Dag Nyholm, Håkan Widner, Trinette Van Vliet, Jennifer Viberg Johansson, Elena Jiltsova, Mats Hansson

Abstract read
In one paragraph

Article in BMC medical ethics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jennifer DrevinCentre for Research Ethics and Bioethics, Uppsala University, Box 564, 751 22, Uppsala, Sweden. Jennifer.drevin@crb.uu.se.
Dag NyholmDepartment of Medical Sciences, Uppsala University Hospital, Uppsala University, 751 85, Uppsala, Sweden.
Håkan WidnerNeurology Clinic, Skåne University Hospital, 221 85, Lund, Sweden.
Trinette Van VlietNeurology Clinic, Skåne University Hospital, 221 85, Lund, Sweden.
Jennifer Viberg JohanssonCentre for Research Ethics and Bioethics, Uppsala University, Box 564, 751 22, Uppsala, Sweden.
Elena JiltsovaDepartment of Medical Sciences, Uppsala University Hospital, Uppsala University, 751 85, Uppsala, Sweden.
Mats HanssonCentre for Research Ethics and Bioethics, Uppsala University, Box 564, 751 22, Uppsala, Sweden. mats.hansson@crb.uu.se.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHuman embryonic stem cells (hESC) as a source for the development of advanced therapy medicinal products are considered for treatment of Parkinson's disease (PD). Research has shown promising results and opened an avenue of great importance for patients who currently lack a disease modifying therapy. The use of hESC has given rise to moral concerns and been the focus of often heated debates on the moral status of human embryos. Approval for marketing is still pending.

objectiveTo Investigate the perspectives and concerns of patients with PD, patients being the directly concerned stakeholders in the ethical discussion.

methodsQualitative semi-structured interviews related to this new therapy in seventeen patients from two Swedish cities.

resultsThe participants expressed various interests related to the use of human embryos for development of medicinal therapies; however, overall, they were positive towards the use of hESC for treatment of PD. It was deemed important that the donating woman or couple made the choice to donate embryos voluntarily. Furthermore, there were concerns that the industry does not always prioritise the patient over profit; thus, transparency was seen as important.

Indexed as

Human Embryonic Stem CellsParkinson DiseaseEmbryo, MammalianFemaleHumansQualitative ResearchAdvanced therapy medicinal productATMPEthicshESCHuman embryonic stem cellsParkinson’s disease

Identifiers

PMID36261826
PMCPMC9579517

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.