Evidence map›Paper›PMID 36261703›Full record

ArticleJournal of cardiovascular translational research2023

Subclinical Leaflet Thrombosis in Supra-annular Transcatheter Aortic Valves: the Role of Leaflet Design.

Dong Qiu, Ali N Azadani

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of cardiovascular translational research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Dong QiuDepartment of Mechanical and Materials Engineering, University of Denver, 2155 E. Wesley Ave, Room 439, Denver, CO, 80208, USA.
Ali N AzadaniDepartment of Mechanical and Materials Engineering, University of Denver, 2155 E. Wesley Ave, Room 439, Denver, CO, 80208, USA. ali.azadani@du.edu.
University of Denver · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Subclinical leaflet thrombosis has been increasingly observed in patients undergoing transcatheter aortic valve replacement. Intra-annular transcatheter aortic valves (TAVs) have a larger neo-sinus volume than supra-annular devices and are potentially at a higher risk of hypoattenuated leaflet thickening (HALT). However, clinical data from randomized clinical trials have shown that approximately one-third of patients undergoing TAVR with intra- or supra-annular devices develop HALT in 1 year. The findings point to the potential role of leaflet design in developing HALT. The study aimed to systematically investigate leaflet kinematics of a supra-annular TAV, Medtronic CoreValve, and determine regions of blood stasis. Fluid-solid interaction simulations demonstrated the limited movement of CoreValve leaflets in the lower belly region that created regions of blood stasis on the surface of the leaflets. The findings provide insights into potential improvements in leaflet design in the next generation of TAVs to reduce the risk of HALT and leaflet immobility.

Indexed as

Aortic Valve StenosisHeart Valve ProsthesisThrombosisTranscatheter Aortic Valve ReplacementAortic ValveHumansProsthesis DesignTreatment OutcomeFlow stasisHypoattenuated leaflet thickeningLeaflet designNeo-sinusSubclinical leaflet thrombosisTranscatheter aortic valve replacement

Identifiers

PMID36261703
OpenAlexW4306809604

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.