Evidence map›Paper›PMID 36261625›Full record

ArticleNature biomedical engineering2022

Brachytherapy via a depot of biopolymer-bound

Jeffrey L Schaal, Jayanta Bhattacharyya, Jeremy Brownstein, Kyle C Strickland, Garrett Kelly, Soumen Saha, Joshua Milligan, Samagya Banskota, Xinghai Li, Wenge Liu and 3 more

Open access · greenAbstract read
In one paragraph

Article in Nature biomedical engineering, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Biomimetic materials for medical applications.Chinese medical journal · 2026
    Review
  3. Article
  4. Article
  5. Development ofDrug delivery and translational research · 2026
    Article
  6. Review
  7. Article
  8. Sequential drug release system: Targeting the tumor ECM for enhanced chemotherapy efficacy.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Cancer Stem Cells in Pancreatic Ductal Adenocarcinoma.International journal of molecular sciences · 2023
    Review
  16. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Jeffrey L SchaalDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
Jayanta BhattacharyyaDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
Jeremy BrownsteinDepartment of Radiation Oncology, Duke University Medical Center, Durham, NC, USA.
Kyle C StricklandDepartment of Pathology, Duke University Medical Center, Durham, NC, USA.
Garrett KellyDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
Soumen SahaDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
Joshua MilliganDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.ORCID 0000-0001-6370-1101
Samagya BanskotaDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
Xinghai LiDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
Wenge LiuDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
David G KirschDepartment of Radiation Oncology, Duke University Medical Center, Durham, NC, USA.ORCID 0000-0002-2086-205X
Michael R ZalutskyDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
Ashutosh ChilkotiDepartment of Biomedical Engineering, Duke University, Durham, NC, USA. chilkoti@duke.edu.ORCID 0000-0002-1569-2228
Duke University · USDuke Medical Center · US

Funding

Advancing Cancer Therapy through Ground Breaking Research in Radiation BiologyR35CA197616 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI David Guy Kirsch · 2016 to 2026
$10.7M
Thermally Targeted Drug Delivery by Elastin BiopolymersR01EB000188 · NIBIB · DUKE UNIVERSITY · PI CHILKOTI, ASHUTOSH · 2002 to 2015
$3.9M
NCI NIH HHS R35 CA197616NIBIB NIH HHS R01 EB000188
6 · The paper itself

Abstract

Locally advanced pancreatic tumours are highly resistant to conventional radiochemotherapy. Here we show that such resistance can be surmounted by an injectable depot of thermally responsive elastin-like polypeptide (ELP) conjugated with iodine-131 radionuclides (

Indexed as

BrachytherapyNanoparticlesPancreatic NeoplasmsAlbumin-Bound PaclitaxelAnimalsBiopolymersElastinIodine RadioisotopesMicePaclitaxelPeptidesTumor MicroenvironmentAlbumin-Bound PaclitaxelBiopolymersElastinIodine-131Iodine RadioisotopesPaclitaxelPeptides

Identifiers

PMID36261625
PMCPMC10389695
OpenAlexW4306810820

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.