Evidence map›Paper›PMID 36261549›Full record

ArticleNature2022

Gut bacteria alleviate smoking-related NASH by degrading gut nicotine.

Bo Chen, Lulu Sun, Guangyi Zeng, Zhe Shen, Kai Wang, Limin Yin, Feng Xu, Pengcheng Wang, Yong Ding, Qixing Nie and 14 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 115 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
115citing papers in PubMed, 2 pooled it
25.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

115 citing papers in PubMed, 2 syntheses or guidelines pooled it, 194 citations in OpenAlex.

  1. Pooled it
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  11. mSystems · 2026
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55 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors at 7 institutions in 3 countries.

Bo Chen *Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing, China.ORCID http://orcid.org/0000-0003-4346-0755
Lulu Sun *Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-8876-5099
Guangyi Zeng *Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing, China.
Zhe Shen *Department of Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Kai Wang *Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing, China.
Limin Yin *Department of Pharmacology, State Key Laboratory of Medical Neurobiology, Key Laboratory of Metabolism and Molecular Medicine, the Ministry of Education, School of Basic Medical Science, Fudan University, Shanghai, China.
Feng XuDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing, China.
Pengcheng WangDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing, China.
Yong DingDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing, China.
Qixing NieDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing, China.
Qing WuDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing, China.
Zhiwei ZhangDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing, China.
Jialin XiaDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing, China.
Jun LinDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing, China.
Yuhong LuoLaboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-8273-8380
Jie CaiLaboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Kristopher W KrauszLaboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Ruimao ZhengDepartment of Anatomy, Histology and Embryology, School of Basic Medical Sciences, Health Science Center, Peking University, Beijing, China.
Yanxue XueNational Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence, Peking University, Beijing, China.
Ming-Hua ZhengNAFLD Research Center, Department of Hepatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. zhengmh@wmu.edu.cn.ORCID http://orcid.org/0000-0003-4984-2631
Yang LiDepartment of Pharmacology, State Key Laboratory of Medical Neurobiology, Key Laboratory of Metabolism and Molecular Medicine, the Ministry of Education, School of Basic Medical Science, Fudan University, Shanghai, China. oceanyangli@fudan.edu.cn.
Chaohui YuDepartment of Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China. zyyyych@zju.edu.cn.
Frank J GonzalezLaboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. gonzalef@mail.nih.gov.ORCID http://orcid.org/0000-0002-7990-2140
Changtao JiangDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing, China. jiangchangtao@bjmu.edu.cn.ORCID http://orcid.org/0000-0002-5206-2372
Peking University · CNNational Institutes of Health · USFirst Affiliated Hospital Zhejiang University · CNFudan University · CNShanghai Medical College of Fudan University · CNWenzhou Medical University · CNZhejiang University · CN

Funding

Xenobiotic receptorsZIABC005562 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI GONZALEZ, FRANK J · 2009 to 2025
$26.9M
Intramural NIH HHS ZIA BC005562
6 · The paper itself

Abstract

Tobacco smoking is positively correlated with non-alcoholic fatty liver disease (NAFLD)

Indexed as

BacteriaIntestinesNicotineNon-alcoholic Fatty Liver DiseaseTobacco SmokingAMP-Activated Protein KinasesAnimalsBacteroidesCeramidesDisease ProgressionHumansMiceSphingomyelin PhosphodiesteraseAMP-Activated Protein KinasesCeramidesNicotineSmpd3 protein, mouseSphingomyelin Phosphodiesterase

Identifiers

PMID36261549
PMCPMC9589931
OpenAlexW4306810394

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.