ArticleNature2022
HRG-9 homologues regulate haem trafficking from haem-enriched compartments.
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 40 papers.
0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
13.2field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 73 citations in OpenAlex.
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- Tunable tau expression in C. elegans neurons reveals that early-AD tau phosphorylation selectively impacts behavior and mitochondrial quality control.Neurobiology of disease · 2026Article
- The crystal structure of human transport and Golgi organization 2 homolog (TANGO2) suggests a cysteine N-terminal nucleophile (Ntn) hydrolase.Acta crystallographica. Section D, Structural biology · 2026Article
- Bafilomycin A1 is a promising therapeutic agent against T. spiralis infection by inhibiting the heme-transporting ATP6V0C/HRG-1 complex.PLoS pathogens · 2026Article
- Progesterone receptor membrane component 1 (PGRMC1) regulates Heme trafficking through mitochondria-ER junctions.Journal of inorganic biochemistry · 2026Article
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- Disruption of heme homeostasis by nuclear receptor Nur77 induces pyroptosis through granzyme B-dependent GSDMC cleavage.Signal transduction and targeted therapy · 2025Article
- Blue light stimulated-autofluorescence green flash of lysosome-related organelles in the intestinal cells of nematodes.G3 (Bethesda, Md.) · 2025Article
- Regulation of iron metabolism in ferroptosis: From mechanism research to clinical translation.Journal of pharmaceutical analysis · 2025Review
- Identification of FLVCR1 as the iron metabolism-related gene of statin-associated diabetes.Acta diabetologica · 2025Article
- Heme allocation in eukaryotic cells relies on mitochondrial heme export through FLVCR1b to cytosolic GAPDH.Nature communications · 2025Article
- Blue light stimulated-autofluorescence green flash of lysosome-related organelles in the intestinal cells of nematodes.bioRxiv : the preprint server for biology · 2025Article
- Mechanisms of heme transport in the mitochondria.Biochemical Society transactions · 2025Review
- TANGO2 binds crystallin alpha B and its loss causes desminopathy.Nature communications · 2025Article
- Plant glutamyl-tRNA reductases coordinate plant and rhizobial heme biosynthesis in nitrogen-fixing nodules.The Plant cell · 2025Article
- TANGO2 is an acyl-CoA binding protein.The Journal of cell biology · 2025Article
- Article
- Cellular Iron Homeostasis.Advances in experimental medicine and biology · 2025Review
Corrections and comments
- Erratum issued
Authors and funding
13 authors at 4 institutions in 2 countries.
Fengxiu Sun *MOE Key Laboratory of Biosystems Homeostasis and Protection, College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, China.
Zhenzhen Zhao *MOE Key Laboratory of Biosystems Homeostasis and Protection, College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, China.
Mathilda M WilloughbySchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, USA.
Shuaiqi ShenMOE Key Laboratory of Biosystems Homeostasis and Protection, College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, China.
Yu ZhouMOE Key Laboratory of Biosystems Homeostasis and Protection, College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, China.
Yiyan ShaoMOE Key Laboratory of Biosystems Homeostasis and Protection, College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, China.
Jing KangMOE Key Laboratory of Biosystems Homeostasis and Protection, College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, China.
Yongtian ChenMOE Key Laboratory of Biosystems Homeostasis and Protection, College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, China.
Mengying ChenMOE Key Laboratory of Biosystems Homeostasis and Protection, College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, China.
Xiaojing YuanDepartment of Pediatrics, Center for Blood Oxygen Transport and Hemostasis, University of Maryland School of Medicine, Baltimore, MD, USA.
Iqbal HamzaDepartment of Pediatrics, Center for Blood Oxygen Transport and Hemostasis, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0003-0045-0610
Amit R ReddiSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, USA.
Caiyong ChenMOE Key Laboratory of Biosystems Homeostasis and Protection, College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, China. chency@zju.edu.cn.ORCID http://orcid.org/0000-0002-7950-4310
Zhejiang University · CNGeorgia Institute of Technology · USUniversity of Maryland, Baltimore · USZhejiang Cancer Hospital · CN
Funding
The Biological Role of Heme in NutritionR01DK074797 · NIDDK · UNIV OF MARYLAND, COLLEGE PARK · PI Iqbal Hamza · 2006 to 2026
$5.4MHeme trafficking and recycling in iron metabolismR01DK125740 · NIDDK · UNIV OF MARYLAND, COLLEGE PARK · PI HAMZA, IQBAL · 2020 to 2023
$1.9MIlluminating Heme Trafficking and Signaling Pathways in Health and DiseaseR35GM145350 · NIGMS · GEORGIA INSTITUTE OF TECHNOLOGY · PI Amit Ram Reddi · 2022 to 2026
$1.9MImaging heme based mitochondrial-cell signaling networks in cell and animal modelR33ES025661 · NIEHS · GEORGIA INSTITUTE OF TECHNOLOGY · PI REDDI, AMIT RAM · 2017 to 2019
$1.7MNIDDK NIH HHS R01 DK074797NIDDK NIH HHS R01 DK125740NIEHS NIH HHS R33 ES025661NIGMS NIH HHS R35 GM145350
Abstract
Haem is an iron-containing tetrapyrrole that is critical for a variety of cellular and physiological processes
Indexed as
Caenorhabditis elegansCaenorhabditis elegans ProteinsHemeAnimalsArrhythmias, CardiacBrain DiseasesHumansMitochondriaMolecular ChaperonesVesicular Transport ProteinsZebrafishZebrafish ProteinsCaenorhabditis elegans ProteinsHemehrg-9 protein, C elegansMolecular Chaperonestango2 protein, zebrafishVesicular Transport ProteinsZebrafish Proteins
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.