Evidence map›Paper›PMID 36261524›Full record

ArticleNature2022

Fast resupply of synaptic vesicles requires synaptotagmin-3.

Dennis J Weingarten, Amita Shrestha, Kessa Juda-Nelson, Sarah A Kissiwaa, Evan Spruston, Skyler L Jackman

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
4.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 53 citations in OpenAlex.

  1. Article
  2. Presynaptic CaCell reports · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Presynaptic CabioRxiv : the preprint server for biology · 2026
    Article
  7. Article
  8. Synaptic Facilitation Enhances the Reliability and Precision of High-Frequency Neurotransmission.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  9. Article
  10. Insights Into the Antigenic Repertoire of Unclassified Synaptic Antibodies.Annals of clinical and translational neurology · 2026
    Article
  11. Munc13-1 couples DAG and CaScience advances · 2026
    Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Impact of Elovl5 Deficiency on Cerebellar Excitatory Synaptic Transmission in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Dennis J WeingartenVollum Institute, Oregon Health and Science University, Portland, OR, USA.
Amita ShresthaVollum Institute, Oregon Health and Science University, Portland, OR, USA.
Kessa Juda-NelsonVollum Institute, Oregon Health and Science University, Portland, OR, USA.
Sarah A KissiwaaVollum Institute, Oregon Health and Science University, Portland, OR, USA.
Evan SprustonVollum Institute, Oregon Health and Science University, Portland, OR, USA.
Skyler L JackmanVollum Institute, Oregon Health and Science University, Portland, OR, USA. jackmans@ohsu.edu.ORCID http://orcid.org/0000-0002-6500-3937
Oregon Health & Science University · US

Funding

Ultrastructure and Single Particle Microscopy CoreP30NS061800 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI AICHER, SUE A · 2009 to 2020
$6.6M
NINDS NIH HHS P30 NS061800
6 · The paper itself

Abstract

Sustained neuronal activity demands a rapid resupply of synaptic vesicles to maintain reliable synaptic transmission. Such vesicle replenishment is accelerated by submicromolar presynaptic Ca

Indexed as

Synaptic VesiclesSynaptotagminsAnimalsCalciumMiceMice, KnockoutNeuronal PlasticitySynaptic TransmissionCalciumSynaptotagminsSyt3 protein, mouse

Identifiers

PMID36261524
OpenAlexW4306810115

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.