ArticleNature2022
Evolution of immune genes is associated with the Black Death.
Erratum issuedOpen access · bronzeAbstract read
In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 104 papers.
0numbers the graph read from it
0cells of the map it votes in
104citing papers in PubMed
43.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
104 citing papers in PubMed, 240 citations in OpenAlex.
- Ancient DNA and Human Physiology.Physiology (Bethesda, Md.) · 2026Review
- A highly prevalent lupus risk haplotype increases IRF7-dependent induction of IFN-α, enhancing antiviral defense and exacerbating autoimmunity.American journal of human genetics · 2026Article
- The Future of Vaccines.Vaccines · 2026Article
- Genomic insights into natural selection in recent human history.Nature reviews. Genetics · 2026Review
- Ancient DNA as a temporal lens: reconstructing evolution, migration, and disease dynamics.Journal, genetic engineering & biotechnology · 2026Review
- Bringing environment back into human evolution: why human genetics needs genome-environment association studies.Human genetics · 2026Review
- Insights into infectious diseases through ancient pathogen genomics.Nature reviews. Microbiology · 2026Review
- Insights into human adaptation from ancient DNA.Nature genetics · 2026Review
- Temporal shifts in polygenic traits track major epidemics in Western Eurasia.bioRxiv : the preprint server for biology · 2026Article
- Review
- Assessing Ancient DNA Sampling Strategies for Natural Selection Inference in Humans Using Allele Frequency Time Series Data.Genome biology and evolution · 2026Article
- Integrated multi-omics profiling identifies genetic loci of African swine fever resistance in pigs.GigaScience · 2026Article
- Ancient DNA study provides clues to leprosy susceptibility in medieval Europe.Genome biology · 2026Article
- Evolutionary Balancing of Genetic Consequence and Innovation in Mammals Through Variable Number Tandem Repeats.Genome biology and evolution · 2026Review
- On the topical issue of assisted dying: the insurmountable challenges of human existence, and the right to exit.Frontiers in public health · 2026Article
- Ancient DNA insights into diverse pathogens and their hosts.Nature reviews. Genetics · 2026Review
- Restoring balance in atopic disorders: insights into type 2 immunity and chronic inflammation.Frontiers in immunology · 2026Review
- Rare and common variants in ERAP1 and ERAP2 selected for in response to Yersinia pestis infection contribute to autoimmune disease including inflammatory bowel disease.Mammalian genome : official journal of the International Mammalian Genome Society · 2025Article
- Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT).Environmental and molecular mutagenesis · 2025Review
- Association of Chromosome 3p21.32 Haplotype Blocks Introgressed from Neanderthals with Critical COVID-19 in a Spanish Cohort.Life (Basel, Switzerland) · 2025Article
44 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
32 authors at 17 institutions in 5 countries.
Jennifer Klunk *McMaster Ancient DNA Centre, Departments of Anthropology, Biology and Biochemistry, McMaster University, Hamilton, Ontario, Canada.ORCID http://orcid.org/0000-0002-6521-8516
Tauras P Vilgalys *Section of Genetic Medicine, Department of Medicine, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-0615-6888
Christian E DemeureYersinia Research Unit, Institut Pasteur, Paris, France.ORCID http://orcid.org/0000-0001-7195-1645
Xiaoheng ChengDepartment of Ecology and Evolution, University of Chicago, Chicago, IL, USA.
Mari ShiratoriSection of Genetic Medicine, Department of Medicine, University of Chicago, Chicago, IL, USA.
Julien MadejYersinia Research Unit, Institut Pasteur, Paris, France.
Rémi BeauYersinia Research Unit, Institut Pasteur, Paris, France.
Derek ElliDepartment of Microbiology, Ricketts Laboratory, University of Chicago, Lemont, IL, USA.
Maria I PatinoSection of Genetic Medicine, Department of Medicine, University of Chicago, Chicago, IL, USA.
Rebecca RedfernCentre for Human Bioarchaeology, Museum of London, London, UK.
Sharon N DeWitteDepartment of Anthropology, University of South Carolina, Columbia, SC, USA.ORCID http://orcid.org/0000-0003-0754-8485
Julia A GambleDepartment of Anthropology, University of Manitoba, Winnipeg, Manitoba, Canada.ORCID http://orcid.org/0000-0001-7486-757X
Jesper L BoldsenDepartment of Forensic Medicine, Unit of Anthropology (ADBOU), University of Southern Denmark, Odense S, Denmark.
Ann CarmichaelHistory Department, Indiana University, Bloomington, IN, USA.ORCID http://orcid.org/0000-0001-7516-7460
Nükhet VarlikDepartment of History, Rutgers University, Newark, NJ, USA.
Katherine EatonMcMaster Ancient DNA Centre, Departments of Anthropology, Biology and Biochemistry, McMaster University, Hamilton, Ontario, Canada.
Jean-Christophe GrenierMontreal Heart Institute, Faculty of Medicine, Université de Montréal, Montréal, Quebec, Canada.ORCID http://orcid.org/0000-0001-7937-5160
G Brian GoldingMcMaster Ancient DNA Centre, Departments of Anthropology, Biology and Biochemistry, McMaster University, Hamilton, Ontario, Canada.
Alison DevaultDaicel Arbor Biosciences, Ann Arbor, MI, USA.
Jean-Marie RouillardDaicel Arbor Biosciences, Ann Arbor, MI, USA.
Vania YotovaCentre Hospitalier Universitaire Sainte-Justine, Montréal, Quebec, Canada.ORCID http://orcid.org/0000-0002-6730-2404
Renata SindeauxCentre Hospitalier Universitaire Sainte-Justine, Montréal, Quebec, Canada.ORCID http://orcid.org/0000-0002-5527-5015
Chun Jimmie YeDivision of Rheumatology, Department of Medicine, University of California, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-6560-3783
Matin BikaranDivision of Rheumatology, Department of Medicine, University of California, San Francisco, CA, USA.
Anne DumaineSection of Genetic Medicine, Department of Medicine, University of Chicago, Chicago, IL, USA.
Jessica F BrinkworthDepartment of Anthropology, University of Illinois Urbana-Champaign, Urbana, IL, USA.
Dominique MissiakasDepartment of Microbiology, Ricketts Laboratory, University of Chicago, Lemont, IL, USA.ORCID http://orcid.org/0000-0001-6482-9633
Guy A RouleauMontreal Neurological Institute-Hospital, McGill University, Montréal, Quebec, Canada.ORCID http://orcid.org/0000-0001-8403-1418
Matthias SteinrückenDepartment of Ecology and Evolution, University of Chicago, Chicago, IL, USA.
Javier Pizarro-CerdáYersinia Research Unit, Institut Pasteur, Paris, France.
Hendrik N PoinarMcMaster Ancient DNA Centre, Departments of Anthropology, Biology and Biochemistry, McMaster University, Hamilton, Ontario, Canada. poinarh@mcmaster.ca.ORCID http://orcid.org/0000-0002-0314-4160
Luis B BarreiroSection of Genetic Medicine, Department of Medicine, University of Chicago, Chicago, IL, USA. lbarreiro@uchicago.edu.ORCID http://orcid.org/0000-0001-9456-367X
University of Chicago · USInstitut Pasteur · FRAastrom Biosciences (United States) · USCentre Hospitalier Universitaire Sainte-Justine · CAMcMaster University · CAUniversity of California, San Francisco · USCanadian Institute for Advanced Research · CAIndiana University Bloomington · USMontreal Heart Institute · CAMontreal Neurological Institute and Hospital · CAMuseum of London · GBRutgers, The State University of New Jersey · USUniversity of Illinois Urbana-Champaign · USUniversity of Manitoba · CAUniversity of Michigan · USUniversity of South Carolina · USUniversity of Southern Denmark · DK
Funding
ULTRASTRUCTURE AND CYTOMORPHOLOGY COREP30DK042086 · NIDDK · UNIVERSITY OF CHICAGO · PI LIU, CAMBRIAN YANGSHAO · 1990 to 2025
$29.8MCharacterizing the impact of Yersinia Pestis to the phenotypic evolution of the human immune systemR01GM134376 · NIGMS · UNIVERSITY OF CHICAGO · PI BARREIRO, LUIS BRUNO · 2019 to 2022
$2.2MPopulation genetic methods to detect population structure and adaptation using modern and ancient genomic datasetsR01GM146051 · NIGMS · UNIVERSITY OF CHICAGO · PI Matthias Steinruecken · 2022 to 2026
$1.7MDeterminants of plague susceptibility and resistanceR56AI146556 · NIAID · UNIVERSITY OF CHICAGO · PI MISSIAKAS, DOMINIQUE M. · 2020 to 2020
$405kCharacterizing variation and adaptation in the immune response to plague (Y. pestis) through single-cell sequencing and ancient genomicsF32GM140568 · NIGMS · UNIVERSITY OF CHICAGO · PI VILGALYS, TAURAS P · 2021 to 2023
$205kNIAID NIH HHS R56 AI146556NIDDK NIH HHS P30 DK042086NIGMS NIH HHS F32 GM140568NIGMS NIH HHS R01 GM134376NIGMS NIH HHS R01 GM146051
Abstract
Infectious diseases are among the strongest selective pressures driving human evolution
Indexed as
DNA, AncientGenetic Predisposition to DiseaseImmunityPlagueSelection, GeneticYersinia pestisAminopeptidasesDatasets as TopicDenmarkEuropeHumansLondonAminopeptidasesDNA, AncientERAP2 protein, human
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.