ArticleNature communications2022
Brainstem networks construct threat probability and prediction error from neuronal building blocks.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- From metabolic intermediary to neurotransmitter: purinergic signaling in neurophysiology and vulnerability of brain circuits.Bioscience reports · 2026Review
- Large-scale electrophysiology at single-spike resolution.Nature reviews. Neuroscience · 2026Review
- Optogenetic stimulation of Purkinje cells in the cerebellar vermis disrupts innate freezing behaviors and is highly aversive.bioRxiv : the preprint server for biology · 2026Article
- Controllability changes pain perception by increasing the precision of expectations.Nature communications · 2025Article
- Short-term synaptic dynamics in the ventrolateral and dorsomedial periaqueductal gray.bioRxiv : the preprint server for biology · 2025Article
- The Spiraling Cognitive-Emotional Brain: Combinatorial, Reciprocal, and Reentrant Macro-organization.Journal of cognitive neuroscience · 2024Article
- Comparative analysis of spike-sorters in large-scale brainstem recordings.bioRxiv : the preprint server for biology · 2024Article
- Article
- Integration of Prior Expectations and Suppression of Prediction Errors During Expectancy-Induced Pain Modulation: The Influence of Anxiety and Pleasantness.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Noncortical cognition: integration of information for close-proximity behavioral problem-solving.Current opinion in behavioral sciences · 2024Article
- Optogenetic inhibition of the caudal substantia nigra inflates behavioral responding to uncertain threat and safety.Behavioral neuroscience · 2023Article
- Optogenetic inhibition of the caudal substantia nigra inflates behavioral responding to uncertain threat and safety.bioRxiv : the preprint server for biology · 2023Article
- Positioning the brainstem within the neural network of threat prediction.Trends in neurosciences · 2023Article
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Abstract
When faced with potential threat we must estimate its probability, respond advantageously, and leverage experience to update future estimates. Threat estimation is the proposed domain of the forebrain, while behaviour is elicited by the brainstem. Yet, the brainstem is also a source of prediction error, a learning signal to acquire and update threat estimates. Neuropixels probes allowed us to record single-unit activity across a 21-region brainstem axis in rats receiving probabilistic fear discrimination with foot shock outcome. Against a backdrop of diffuse behaviour signaling, a brainstem network with a dorsal hub signaled threat probability. Neuronal function remapping during the outcome period gave rise to brainstem networks signaling prediction error and shock on multiple timescales. The results reveal brainstem networks construct threat probability, behaviour, and prediction error signals from neuronal building blocks.
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