ArticleEye (London, England)2023
Repeatability, reproducibility and agreement between three different diagnostic imaging platforms for tear film evaluation of normal and dry eye disease.
Article in Eye (London, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Evaporative dry eye disease due to meibomian gland dysfunction: Preferred practice pattern guidelines for diagnosis and treatment.Indian journal of ophthalmology · 2023Guideline
- Ocular Surface Recovery Following Corrective Eyelid Surgery: Course, Predictors, and Perioperative Management Implications.Diagnostics (Basel, Switzerland) · 2026Article
- Reference Estimates of Mean Tear Film Lipid Layer Thickness Measured with LipiViewJournal of clinical medicine · 2026Review
- Article
- Diagnostic Agreement Between Invasive and Non-invasive Assessments for Preoperative Dry Eye Disease Screening in Patients with Cataracts.Ophthalmology and therapy · 2026Article
- Efficacy of Manuka honey eye drops in managing dry eye disease after cataract surgery: a prospective controlled study.Frontiers in ophthalmology · 2026Article
- Mechanisms and Safety of Therapeutic Strategies in Meibomian Gland Dysfunction: A Narrative Review.Ophthalmic research · 2026Review
- Agreement and repeatability of ocular surface function using the S390L Firefly WDR slitlamp compared with Keratograph 5M.Scientific reports · 2025Article
- Repeatability of lipid layer thickness using LipiView® following removal of contact lenses and its relationship to comfort.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2025Article
- Layer-by-layer tear film measurement in patients with dry eye and meibomian gland dysfunction.International journal of ophthalmology · 2025Article
- Diagnostic Performance of Visionix VX120+ Platform for Dry Eye Screening.Diagnostics (Basel, Switzerland) · 2024Article
- Evaluation of tear film function by Oculus Keratograph 5M and IDRA ocular surface analyser.International ophthalmology · 2024Article
- Temporal Progression of Entry Factors into the Vicious Circle of Dry Eye in Untreated Sufferers.Life (Basel, Switzerland) · 2024Article
- Safety and Efficacy of Photocatalytic Micro-Mist Desktop Humidifier for Dry Eye Caused by Digital Environment: A Randomized Controlled Trial.Journal of clinical medicine · 2024Article
- Post-Blink Blur Time-A Simple Test to Detect Dry Eye-Related Visual Disturbances.Journal of clinical medicine · 2024Article
- Agreement between invasive and noninvasive measurement of tear film breakup time.Scientific reports · 2024Article
- A Comprehensive Study on Tear Meniscus Height Inter-Eye Differences in Aqueous Deficient Dry Eye Diagnosis.Journal of clinical medicine · 2024Article
- Efficacy assessment of liposome crosslinked hyaluronic acid and standard hyaluronic acid eye drops for dry eye disease management: a comparative study employing the ocular surface analyzer and subjective questionnaires.Frontiers in medicine · 2024Article
- Tolerability of Diquas LX on tear film and meibomian glands findings in a real clinical scenario.PloS one · 2024Article
- Moisture chamber goggles for the treatment of postoperative dry eye in patients receiving SMILE and FS-LASIK surgery.BMC ophthalmology · 2023Article
Corrections and comments
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Authors and funding
5 authors.
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Abstract
purposeTo assess the repeatability and reliability of different commercially available diagnostic platforms in the objective assessment of tear film parameters and if there exists any agreement between them.
methodsThirty healthy individuals (N = 60 eyes) and fifteen DED patients (N = 30 eyes) had their tear film parameters (Lipid layer thickness (LLT), Tear meniscus height (TMH), Non-invasive tear break up time (NIBUT)) assessed using three instruments - LipiView® II, IDRA ocular surface analyser (IDRA-OSA) and Oculus keratograph 5 M (K5M). Bland-Altman analysis and linear mixed effects modelling & Generalized Linear Hypothesis Test were used for analysis and coefficient of variation (CoV).
resultsThere is poor repeatability but good reproducibility of LLT values measured with Lipiview, or IDRA. NIBUT using K5M & IDRA-OSA shows good repeatability and reproducibility in control group but poor repeatability in DED patients. TMH values obtained with K5M or IDRA-OSA had poor repeatability with high CoV. Between two observers, good reproducibility is observed for TMH and NIBUT values using both K5M & IDRA-OSA but not for LLT values. Between instruments, all the measurements (LLT, NIBUT and TMH) were significantly different on Bland Altman analysis.
conclusionNo two dry eye diagnostic platforms can be used interchangeably and non-invasive tear film values should be interpreted keeping in mind the individual machine's variability. The high coefficient of variation in DED patients compared to normal reflects inherent variability in tear film irrespective of the device used.
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