Evidence map›Paper›PMID 36261468›Full record

ArticleSchizophrenia (Heidelberg, Germany)2022

CCRT and aerobic exercise: a randomised controlled study of processing speed, cognitive flexibility, and serum BDNF expression in schizophrenia.

Yuanyuan Dai, Hongyan Ding, Xiaozi Lu, Xiumei Wu, Chunhua Xu, Tingting Jiang, Liang Ming, Zhong Xia, Chuanfu Song, Hongxian Shen and 2 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Schizophrenia (Heidelberg, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Yuanyuan DaiThe Fourth People's Hospital of Wuhu, Wuhu, 241000, China.
Hongyan DingThe Fourth People's Hospital of Wuhu, Wuhu, 241000, China.
Xiaozi LuQingdao Mental Health Center, Qingdao, 266034, China.
Xiumei WuThe Fourth People's Hospital of Wuhu, Wuhu, 241000, China.
Chunhua XuThe Fourth People's Hospital of Wuhu, Wuhu, 241000, China.
Tingting JiangThe Fourth People's Hospital of Wuhu, Wuhu, 241000, China.
Liang MingThe Fourth People's Hospital of Wuhu, Wuhu, 241000, China.
Zhong XiaThe Fourth People's Hospital of Wuhu, Wuhu, 241000, China.
Chuanfu SongThe Fourth People's Hospital of Wuhu, Wuhu, 241000, China.
Hongxian ShenNational Clinical Research Center for Mental Disorders, and Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, 410011, China. shenhx2018@csu.edu.cn.ORCID http://orcid.org/0000-0002-1714-5084
Wei HaoNational Clinical Research Center for Mental Disorders, and Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, 410011, China. weihao57@csu.edu.cn.ORCID http://orcid.org/0000-0003-4681-1178
Shucai HuangThe Fourth People's Hospital of Wuhu, Wuhu, 241000, China. schuang1986@126.com.
The Fourth People's Hospital · CNCentral South University · CNQingdao Mental Health Center · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Computerised cognitive remediation therapy (CCRT) and aerobic exercise are often used to rehabilitate social functioning in patients with schizophrenia. However, there is limited knowledge regarding the effects of CCRT combined with aerobic exercise on cognitive function and brain-derived neurotrophic factor (BDNF) levels in patients with schizophrenia and cognitive impairment. Ninety-six patients with schizophrenia and cognitive impairment were included in this study and randomly divided into control, aerobic exercise (AE), and CCRT combined with aerobic exercise (CAE) groups. Changes in processing speed and cognitive flexibility at week 8 were evaluated as primary and secondary cognitive outcomes using the Trail Making Test: Part A, the Brief Assessment of Cognition in Schizophrenia: Symbol Coding Test, and the Stroop Colour-Word Test. Positive and Negative Syndrome Scale (PANSS) scores and serum BDNF expression were determined as other secondary outcomes. The CAE group showed significantly better performance in terms of changes in processing speed and cognitive flexibility than the control and AE groups at week 8 (p < 0.05); however, no significant improvements in processing speed and cognitive flexibility were found between the control and AE groups. The CAE group showed significant improvements in the PANSS negative symptoms than the control group at week 8 (p < 0.05), but the AE group showed no significant difference in the changes of PANSS negative symptoms when compared with the other two groups. The CAE group and AE group showed a greater increase in serum BDNF levels than the control group (p < 0.01), but there was no significant difference in serum BDNF expression between the CAE group and AE group. In conclusion, 8-week CCRT combined with aerobic exercise may improve some cognitive performance and negative symptoms in patients with schizophrenia. Aerobic exercise may have an immediate effect on serum BDNF levels rather than cognitive function.

Identifiers

PMID36261468
PMCPMC9581987
OpenAlexW4306914302

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.