ArticleNature communications2022
Host genetic factors related to innate immunity, environmental sensing and cellular functions are associated with human skin microbiota.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.
- The role of skin microbiota in lichen planus from a Mendelian randomization perspective.Archives of dermatological research · 2025Pooled it
- Article
- Bidirectional mediation between microbiota and immune system in Parkinson disease: A two-sample Mendelian randomization study.Medicine · 2026Article
- Genotype-Environment-Driven Dysbiosis in the Skin Microbiome of Ichthyosis.The Journal of investigative dermatology · 2026Article
- Host mScientific reports · 2026Article
- Genomics of host-microbiome interactions in humans.Nature reviews. Genetics · 2026Review
- Exploring the Role of Skin Microbiota in Autoimmune Skin Diseases from a Bidirectional Mendelian Randomization Perspective.Clinical, cosmetic and investigational dermatology · 2026Article
- The active immune role of keratinocytes: from passive targets to key hubs in psoriatic inflammation.Frontiers in immunology · 2026Review
- Unravelling the causal link between gut microbiota and acne risk using a genetic approach.Skin health and disease · 2025Article
- Genetic insights into the causal role of metabolic, immune, and microbial factors in migraine.Neurogenetics · 2025Article
- Functionally enriched human polymorphisms associate to species in the chronic wound microbiome.NPJ biofilms and microbiomes · 2025Article
- Elucidation of novel diagnostic biomarkers and therapeutic targets in colorectal carcinoma: an integrative approach leveraging multi-omics, computational biology, and single-cell sequencing technologies.Mammalian genome : official journal of the International Mammalian Genome Society · 2025Article
- Restoration of the human skin microbiome following immune recovery after hematopoietic stem cell transplantation.Cell host & microbe · 2025Article
- Inflammation biomarkers mediate causal inference of the effect of skin microbiota on the risk of allergic diseases.AMB Express · 2025Article
- The human skin microbiome in health.Journal of the American Academy of Dermatology · 2025Review
- A Mendelian randomization analysis reveals the role of the skin microbiota in systemic lupus erythematosus.Clinical rheumatology · 2025Article
- Mendelian randomization study reveals causal association between skin microbiome and skin cancers.Scientific reports · 2025Article
- Decoding the skin microbiota: A Mendelian randomization study reveals new insights into acne causality.Medicine · 2025Article
- Mendelian randomization analysis unveils causal relationships between skin microbiota and osteomyelitis.Archives of dermatological research · 2025Article
- A human skin microbiome reference catalog and the skin microbial landscape of plateau adults.iMetaOmics · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite the increasing knowledge about factors shaping the human microbiome, the host genetic factors that modulate the skin-microbiome interactions are still largely understudied. This contrasts with recent efforts to characterize host genes that influence the gut microbiota. Here, we investigated the effect of genetics on skin microbiota across three different skin microenvironments through meta-analyses of genome-wide association studies (GWAS) of two population-based German cohorts. We identified 23 genome-wide significant loci harboring 30 candidate genes involved in innate immune signaling, environmental sensing, cell differentiation, proliferation and fibroblast activity. However, no locus passed the strict threshold for study-wide significance (P < 6.3 × 10
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.