Evidence map›Paper›PMID 36261442›Full record

ReviewNPJ biofilms and microbiomes2022

Filamentous fungal biofilms: Conserved and unique aspects of extracellular matrix composition, mechanisms of drug resistance and regulatory networks in Aspergillus fumigatus.

Shuai Liu, Francois Le Mauff, Donald C Sheppard, Shizhu Zhang

Open access · goldAbstract readReview
In one paragraph

Review in NPJ biofilms and microbiomes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 52 citations in OpenAlex.

  1. Toxicogenetic profiling of an antifungal lawsone silver salt: in silico and in vitro analysis in 2D and 3D mammalian models.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
    Article
  2. Article
  3. Article
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  5. Article
  6. Article
  7. Article
  8. Antibiofilm activity of terbinafine, itraconazole and their combination against Sporothrix brasiliensis yeast-like form's biofilms.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026
    Article
  9. Article
  10. Functional and molecular characterization ofJournal of medical microbiology · 2026
    Article
  11. Review
  12. Biofilm Formation inMicroorganisms · 2026
    Article
  13. Review
  14. Review
  15. Article
  16. Pathogenesis and Triazole Resistance inInfection and drug resistance · 2026
    Review
  17. Article
  18. Article
  19. Azole-ResistantJournal of fungi (Basel, Switzerland) · 2025
    Review
  20. TheJournal of fungi (Basel, Switzerland) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Shuai LiuJiangsu Key Laboratory for Microbes and Functional Genomics, Jiangsu Engineering and Technology Research Center for Microbiology, College of Life Sciences, Nanjing Normal University, Nanjing, China.ORCID 0000-0001-9147-3708
Francois Le MauffDepartment of Microbiology and Immunology, Faculty of Medicine, McGill University, Montreal, QC, Canada.ORCID 0000-0003-0712-5837
Donald C SheppardDepartment of Microbiology and Immunology, Faculty of Medicine, McGill University, Montreal, QC, Canada. don.sheppard@mcgill.ca.ORCID 0000-0001-8877-880X
Shizhu ZhangJiangsu Key Laboratory for Microbes and Functional Genomics, Jiangsu Engineering and Technology Research Center for Microbiology, College of Life Sciences, Nanjing Normal University, Nanjing, China. szzhang@njnu.edu.cn.ORCID 0000-0002-0283-3714
McGill University Health Centre · CANanjing Normal University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The filamentous fungus Aspergillus fumigatus is an ubiquitous mold that can cause invasive pulmonary infections in immunocompromised patients. Within the lung, A. fumigatus forms biofilms that can enhance resistance to antifungals and immune defenses, highlighting the importance of defining the mechanisms underlying biofilm development and associated emergent properties. A. fumigatus biofilms display a morphology and architecture that is distinct from bacterial and yeast biofilms. Moreover, A. fumigatus biofilms display unique characteristics in the composition of their extracellular matrix (ECM) and the regulatory networks governing biofilm formation. This review will discuss our current understanding of the form and function of A. fumigatus biofilms, including the unique components of ECM matrix, potential drug resistance mechanisms, the regulatory networks governing A. fumigatus biofilm formation, and potential therapeutics targeting these structures.

Indexed as

Antifungal AgentsAspergillus fumigatusBiofilmsDrug ResistanceExtracellular MatrixFungiHumansAntifungal Agents

Identifiers

PMID36261442
PMCPMC9581972
OpenAlexW4306755851

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.