ArticleNature communications2022
The genome and lifestage-specific transcriptomes of a plant-parasitic nematode and its host reveal susceptibility genes involved in trans-kingdom synthesis of vitamin B5.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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40 citing papers in PubMed, 83 citations in OpenAlex.
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- Genomic and Transcriptomic Insights into the Evolution and Parasitic Strategy of the Woody-Plant NematodeMolecular plant-microbe interactions : MPMI · 2026Article
- The potato cyst nematode Globodera pallida overcomes major potato resistance through selection on standing variation at a single locus.The New phytologist · 2026Article
- Molecular mimicry and trafficking of peptide effectors in sedentary nematodes: emerging drivers of feeding site formation and host signaling hijack.Crop health · 2026Review
- RNA tomography reveals spatial gene expression maps of Arabidopsis thaliana roots infected with Heterodera schachtii.The New phytologist · 2026Article
- NUDIX hydrolases target specific inositol pyrophosphates and regulate phosphate homeostasis and bacterial pathogen susceptibility in Arabidopsis.Journal of integrative plant biology · 2025Article
- High-resolution genome assembly and linkage mapping in Meloidogyne hapla reveal non-canonical telomere repeats and recombination hotspots associated with effector proteins.PLoS pathogens · 2025Article
- A trehalase-derived MAMP triggers LecRK-V-mediated immune responses inScience advances · 2025Article
- Biological Activity Evaluation AgainstMolecules (Basel, Switzerland) · 2025Article
- Diet-regulated transcriptional plasticity of plant parasites in plant-mutualist environments.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Damage activates EXG1 and RLP44 to suppress vascular differentiation during regeneration in Arabidopsis.Plant communications · 2025Article
- The SUbventral-Gland Regulator (SUGR-1) of nematode virulence.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Insights from draft genomes of Heterodera species isolated from field soil samples.BMC genomics · 2025Article
- A user-friendly software to accurately count and measure cysts from the parasitic nematode Heterodera glycines.Scientific reports · 2025Article
- Genome Assembly and Annotation of the Alfalfa Cyst Nematode (Journal of nematology · 2025Article
- Identification of genes involved in the tomato root response to Globodera rostochiensis parasitism under varied light conditions.Journal of applied genetics · 2025Article
- Genomic and Transcriptomic Analysis of the Polyploidy Cyst Nematode,International journal of molecular sciences · 2025Article
- Antagonistic Efficacy of Symbiotic BacteriumJournal of microbiology and biotechnology · 2024Article
- The origin, deployment, and evolution of a plant-parasitic nematode effectorome.PLoS pathogens · 2024Article
- A gene with a thousand alleles: The hyper-variable effectors of plant-parasitic nematodes.Cell genomics · 2024Article
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33 authors at 11 institutions in 7 countries.
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Abstract
Plant-parasitic nematodes are a major threat to crop production in all agricultural systems. The scarcity of classical resistance genes highlights a pressing need to find new ways to develop nematode-resistant germplasm. Here, we sequence and assemble a high-quality phased genome of the model cyst nematode Heterodera schachtii to provide a platform for the first system-wide dual analysis of host and parasite gene expression over time, covering all major parasitism stages. Analysis of the hologenome of the plant-nematode infection site identified metabolic pathways that were incomplete in the parasite but complemented by the host. Using a combination of bioinformatic, genetic, and biochemical approaches, we show that a highly atypical completion of vitamin B5 biosynthesis by the parasitic animal, putatively enabled by a horizontal gene transfer from a bacterium, is required for full pathogenicity. Knockout of either plant-encoded or now nematode-encoded steps in the pathway significantly reduces parasitic success. Our experiments establish a reference for cyst nematodes, further our understanding of the evolution of plant-parasitism by nematodes, and show that congruent differential expression of metabolic pathways in the infection hologenome represents a new way to find nematode susceptibility genes. The approach identifies genome-editing-amenable targets for future development of nematode-resistant crops.
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