Evidence map›Paper›PMID 36261335›Full record

ArticleJournal of clinical and experimental hematopathology : JCEH2022

Acute undifferentiated leukemia limited to neck lymph nodes and a large mediastinal mass.

Kenta Hayashino, Masayuki Matsuda, Keigo Fujishita, Jun Iwata, Miki Mizobuchi, Munenori Uemura, Kenji Yorita, Akiko Maeshima, Toshi Imai

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PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical and experimental hematopathology : JCEH, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 77% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Kenta HayashinoDepartment of hematology, Kochi health sciences center, Kochi, Japan.
Masayuki MatsudaDepartment of hematology, Kochi health sciences center, Kochi, Japan.
Keigo FujishitaDepartment of hematology, Kochi health sciences center, Kochi, Japan.
Jun IwataDepartment of diagnostic of pathology, Kochi health sciences center, Kochi, Japan.
Miki MizobuchiDepartment of hematology, Japanese Red Cross Kochi Hospital, Kochi, Japan.
Munenori UemuraDepartment of hematology, Japanese Red Cross Kochi Hospital, Kochi, Japan.
Kenji YoritaDepartment of diagnostic pathology, Japanese Red Cross Kochi Hospital, Kochi, Japan.
Akiko MaeshimaDepartment of Pathology, National Cancer Center Hospital, Tokyo, Japan.
Toshi ImaiDepartment of hematology, Kochi health sciences center, Kochi, Japan.
University of Kochi · JPJapanese Red Cross Kochi Hospital · JPTokyo National Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the 2016 update of the World Health Organization (WHO) classification of myeloid neoplasms, acute undifferentiated leukemia (AUL) was defined by a lack of lineage-specific markers. AUL has very poor prognosis and no established therapies due to its rarity. We report a case of a 31-year-old man with AUL who showed complete molecular response to an acute lymphoblastic leukemia (ALL)-based regimen and received allogeneic hematopoietic stem cell transplantation. The patient's blast cells were CD7-positive and localized to lymph nodes in the neck and to a large mediastinal mass; there was also rearrangement of the T-cell receptor delta locus. Although the tumor showed characteristics of T-cell lymphoblastic lymphoma, it was categorized as AUL based on WHO classification. This case suggests that a high-intensity conditioning regimen could be effective for rare cases of AUL that present only in the extramedullary mass, and chemotherapy for AUL should be selected based on the characteristics of the blasts.

Indexed as

Leukemia, Myeloid, AcutePrecursor Cell Lymphoblastic Leukemia-LymphomaAdultHumansLymph NodesLymphocytesMalePrognosisacute undifferentiated leukemiaallogeneic hematopoietic stem cell transplantationconditioning regimenrare leukemia

Identifiers

PMID36261335
PMCPMC9898720
OpenAlexW4306914986

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.