ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2022
Structure-Function Dissociations of Human Hippocampal Subfield Stiffness and Memory Performance.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- A NOVEL BAYESIAN FRAMEWORK UNCOVERING BRAIN CONNECTIVITY-TO-SHAPE RELATIONSHIP IN PRECLINICAL ALZHEIMER'S DISEASE.The annals of applied statistics · 2026Article
- Hippocampal tissue mechanics are sensitive to fluctuations in oestrogen across the rat oestrous cycle.Brain communications · 2026Article
- Hippocampal relational memory and spatial reconstruction: where are we at and where are we bound?Frontiers in cognition · 2026Review
- Longitudinal non-linear changes in the microstructure of the hippocampal subfields in older adults.Neurobiology of aging · 2025Article
- Brain age prediction and early neurodegeneration detection using contrastive learning on brain biomechanics: a retrospective, multicentre study.EBioMedicine · 2025Article
- Putamen Stiffness Declines with Age and Is Associated with Implicit Sequence Learning Outcomes.Brain sciences · 2025Article
- Change in Mechanical Property of Rat Brain Suffering from Chronic High Intraocular Pressure.Bioengineering (Basel, Switzerland) · 2025Article
- The pulsing brain: state of the art and an interdisciplinary perspective.Interface focus · 2025Review
- Brain mechanical properties predict longitudinal cognitive change in aging and Alzheimer's disease.Neurobiology of aging · 2025Article
- Mechanical Properties of the Cortex in Older Adults and Relationships With Personality Traits.Human brain mapping · 2025Article
- MRI-based whole-brain elastography and volumetric measurements to predict brain age.Biology methods & protocols · 2025Article
- Acute effects of high-intensity exercise on brain mechanical properties and cognitive function.Brain imaging and behavior · 2024Article
- Magnetic resonance elastography captures a transient benefit of exercise intervention on forebrain stiffness in a rat model of fetal alcohol spectrum disorders.Alcohol, clinical & experimental research · 2024Article
- Associations between vascular health, brain stiffness and global cognitive function.Brain communications · 2024Article
- Vascular determinants of hippocampal viscoelastic properties in healthy adults across the lifespan.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Aging and neurodegenerative diseases lead to decline in thinking and memory ability. The subfields of the hippocampus (HCsf) play important roles in memory formation and recall. Imaging techniques sensitive to the underlying HCsf tissue microstructure can reveal unique structure-function associations and their vulnerability in aging and disease. The goal of this study was to use magnetic resonance elastography (MRE), a noninvasive MR imaging-based technique that can quantitatively image the viscoelastic mechanical properties of tissue to determine the associations of HCsf stiffness with different cognitive domains across the lifespan. Eighty-eight adult participants completed the study (age 23-81 years, male/female 36/51), in which we aimed to determine which HCsf regions most strongly correlated with different memory performance outcomes and if viscoelasticity of specific HCsf regions mediated the relationship between age and performance. Our results revealed that both interference cost on a verbal memory task and relational memory task performance were significantly related to cornu ammonis 1-2 (CA1-CA2) stiffness (
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