Evidence map›Paper›PMID 36261134›Full record

ArticleThe journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians2022

Clinical and histopathological correlates of intestinal repair in preterm infants following surgical necrotizing enterocolitis.

Parvesh Mohan Garg, Charles Middleton, Mengna Zhang, Jaslyn L Paschal, Ashish R Kurundkar, Hardik Sonani, Neha Varshney, William B Hillegass

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

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  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Parvesh Mohan GargDepartment of Pediatrics/Neonatology, University of Mississippi Medical Center, Jackson, MS, USA.ORCID 0000-0001-5949-7304
Charles MiddletonDepartment of Pathology, University of Mississippi Medical Center, Jackson, MS, USA.
Mengna ZhangDepartment of Data Sciences, University of Mississippi Medical Center, Jackson, MS, USA.
Jaslyn L PaschalDepartment of Pediatrics/Neonatology, University of Mississippi Medical Center, Jackson, MS, USA.
Ashish R KurundkarDepartment of Pathology, University of Alabama, Birmingham, AL, USA.
Hardik SonaniDepartment of Pathology, University of Mississippi Medical Center, Jackson, MS, USA.
Neha VarshneyDepartment of Pathology, University of Mississippi Medical Center, Jackson, MS, USA.
William B HillegassDepartment of Data Sciences, University of Mississippi Medical Center, Jackson, MS, USA.
Jackson Memorial Hospital · USUniversity of Alabama at Birmingham · US

Funding

Tracking and Evaluation CoreU54GM115428 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI HALL, JOHN E · 2016 to 2025
$38.2M
NIGMS NIH HHS U54 GM115428
6 · The paper itself

Abstract

objectiveWe sought to determine the clinical and histopathological factors linked with intestinal repair and its correlation with clinical outcomes in preterm infants following surgical necrotizing enterocolitis (NEC).

methodsA retrospective study has compared clinical and histopathological characteristics between preterm infants with histopathological reparative changes versus non-reparative changes in resected intestinal tissue following surgical treatment of NEC. Reparative changes were defined as microscopic evidence of neovascularization, increased fibroblasts or myofibroblasts, and epithelial regeneration during histopathological examination of the most affected area of resected intestinal tissue.

resultsThe infants with reparative changes (53/148) had significantly lower median birth weight (725 [650-963] vs. 920 [690-1320];

conclusionIn neonates with surgical NEC, the histopathological findings in the resected bowel are significantly associated with clinical characteristics, other histopathological findings, and outcomes. The presence of reparative changes consistent with healing is significantly associated with Apgar score, Penrose drain therapy, longer time from NEC diagnosis to surgery, and lower burden of inflammation in the resected bowel tissue in multivariable analyses. Routine histopathological grading of resected bowel and optimal use of Penrose drain therapy warrant further investigation in the care of neonates with surgical NEC.

Indexed as

Enterocolitis, NecrotizingFetal DiseasesInfant, Newborn, DiseasesBirth WeightFemaleHumansInfantInfant, NewbornInfant, PrematureInflammationRetrospective StudiesNecrotizing enterocolitisoutcomespreterm infantsreparative changes

Identifiers

PMID36261134
PMCPMC10363770
OpenAlexW4306837159

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.