Reducing misclassification bias in severe malaria research.

Matthew M Ippolito, Matthew L Robinson

Abstract readComment

In one paragraph

Article in Cell reports. Medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it

0cells of the map it votes in

4citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

Estimating malaria attributable fraction using quantitative PCR in a longitudinal cohort in Eastern Uganda.medRxiv : the preprint server for health sciences · 2026
Article
Program Evaluation of Community Case Management with Reactive Test and Treat for Malaria in a High-Transmission Setting.The American journal of tropical medicine and hygiene · 2025
Article
Supplementing routine hospital surveillance of malaria to capture excess mortality and epidemiological trends: a five-year observational study.Frontiers in malaria · 2024
Article
Long-Lasting Insecticide-Treated Net Use Gaps and Severity Predictors in a Pre-Elimination Landscape: A Retrospective Observational Study in Mberengwa, Zimbabwe.Inquiry : a journal of medical care organization, provision and financing
Observational

4 · The record

Corrections and comments

Comment on
Hidden Biomass of Intact Malaria Parasites in the Human Spleen.2021
Comment on
Improving the diagnosis of severe malaria in African children using platelet counts and plasma2022

5 · Who and what money

Authors and funding

2 authors.

Matthew M IppolitoDepartment of Medicine, Divisions of Clinical Pharmacology and Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA; W. Harry Feinstone Department of Molecular Microbiology and Immunology, Malaria Research Institute, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA. Electronic address: mippolito@jhu.edu.

Matthew L RobinsonDepartment of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

Funding

Clinical Pharmacology of Malaria Control and Elimination: Pharmacodynamics ofArtemisinin-based Combination Agents and their Barriers to Drug ResistanceK23AI139343 · NIAID · JOHNS HOPKINS UNIVERSITY · PI IPPOLITO, MATTHEW MICHAEL · 2020 to 2023

$773k

NIAID NIH HHS K23 AI139343

6 · The paper itself

Abstract

By incorporating platelets and PfHRP2 into standard case definitions of severe falciparum malaria, Watson et al.

Indexed as

MalariaAntigens, ProtozoanBiasBlood PlateletsHumansProtozoan ProteinsSelection BiasAntigens, ProtozoanProtozoan Proteins

Identifiers

PMID36260989

DOI10.1016/j.xcrm.2022.100789

PMCPMC9589118

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.