Evidence map›Paper›PMID 36260745›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Responsiveness to interleukin-15 therapy is shared between tissue-resident and circulating memory CD8

Nicholas N Jarjour, Kelsey M Wanhainen, Changwei Peng, Noah V Gavil, Nicholas J Maurice, Henrique Borges da Silva, Ryan J Martinez, Talia S Dalzell, Matthew A Huggins, David Masopust and 2 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Evolving role of CD8Frontiers in immunology · 2026
    Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. UFL1 promotes survival and function of virtual memory CD8 T cells.Journal of immunology (Baltimore, Md. : 1950) · 2025
    Article
  11. Review
  12. Review
  13. Article
  14. Functional Diversity of Memory CD8 T Cells is Spatiotemporally Imprinted.bioRxiv : the preprint server for biology · 2024
    Article
  15. Article
  16. Review
  17. Insights into phenotypic and functional CD8Immunological reviews · 2023
    Review
  18. Review
  19. Exploring Mast Cell-CD8 T Cell Interactions in Inflammatory Skin Diseases.International journal of molecular sciences · 2023
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Nicholas N JarjourCenter for Immunology, University of Minnesota, Minneapolis, MN 55455.ORCID 0000-0001-9400-4448
Kelsey M WanhainenCenter for Immunology, University of Minnesota, Minneapolis, MN 55455.
Changwei PengCenter for Immunology, University of Minnesota, Minneapolis, MN 55455.ORCID 0000-0002-0710-9573
Noah V GavilCenter for Immunology, University of Minnesota, Minneapolis, MN 55455.
Nicholas J MauriceCenter for Immunology, University of Minnesota, Minneapolis, MN 55455.ORCID 0000-0002-2667-472X
Henrique Borges da SilvaCenter for Immunology, University of Minnesota, Minneapolis, MN 55455.
Ryan J MartinezCenter for Immunology, University of Minnesota, Minneapolis, MN 55455.
Talia S DalzellCenter for Immunology, University of Minnesota, Minneapolis, MN 55455.
Matthew A HugginsCenter for Immunology, University of Minnesota, Minneapolis, MN 55455.
David MasopustCenter for Immunology, University of Minnesota, Minneapolis, MN 55455.ORCID 0000-0002-9440-3884
Sara E HamiltonCenter for Immunology, University of Minnesota, Minneapolis, MN 55455.
Stephen C JamesonCenter for Immunology, University of Minnesota, Minneapolis, MN 55455.ORCID 0000-0001-9137-1146
University of Minnesota · US

Funding

T Cell HomeostasisR01AI038903 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI STEPHEN C JAMESON · 2001 to 2026
$5.9M
T cell homeostasisR37AI038903 · NIAID · UNIVERSITY OF MINNESOTA · PI JAMESON, STEPHEN C · 2006 to 2015
$3.6M
DEFINING THE FUNCTION OF EXTRACELLULAR ATP SENSING FOR MEMORY CD8+ T CELL GENERATION AND LONGEVITYR00AI139381 · NIAID · MAYO CLINIC ARIZONA · PI BORGES DA SILVA, HENRIQUE · 2020 to 2021
$498k
Profiling and leveraging bystander T cells within the tumor microenvironmentK00CA245735 · NCI · UNIVERSITY OF MINNESOTA · PI MAURICE, NICHOLAS JOSEPH · 2022 to 2025
$372k
Investigating mechanisms of peptide alarm therapyF30CA253992 · NCI · UNIVERSITY OF MINNESOTA · PI GAVIL, NOAH VEIS · 2020 to 2023
$167k
Role of P2RX7 in making CD8+ T cells for tumor immunotherapy.F30CA250321 · NCI · UNIVERSITY OF MINNESOTA · PI WANHAINEN, KELSEY · 2020 to 2023
$161k
MECHANISM AND ROLE OF T CELL RECEPTOR ANTAGONISMR29AI038903 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI JAMESON, STEPHEN C · 1996 to 2000
$111k
Defining the function of extracellular ATP sensing for memory CD8+ T cell generation and longevityK99AI139381 · NIAID · UNIVERSITY OF MINNESOTA · PI BORGES DA SILVA, HENRIQUE · 2019 to 2019
$100k
Profiling and leveraging bystander T cells within the tumor microenvironmentF99CA245735 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI MAURICE, NICHOLAS JOSEPH · 2019 to 2021
$94k
NCI NIH HHS F30 CA250321NCI NIH HHS F30 CA253992NCI NIH HHS F99 CA245735NCI NIH HHS K00 CA245735NIAID NIH HHS K99 AI139381NIAID NIH HHS R00 AI139381NIAID NIH HHS R01 AI038903NIAID NIH HHS R29 AI038903NIAID NIH HHS R37 AI038903
6 · The paper itself

Abstract

Interleukin-15 (IL-15) is often considered a central regulator of memory CD8

Indexed as

CD8-Positive T-LymphocytesInterleukin-15Immunologic MemoryT-Lymphocyte SubsetsInterleukin-15CD8+ T cell memorycytokinetissue-resident memory

Identifiers

PMID36260745
PMCPMC9618124
OpenAlexW4306842291

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.