Evidence map›Paper›PMID 36260680›Full record

ArticleScience advances2022

Oxysterol misbalance critically contributes to Wilson disease pathogenesis.

Som Dev, Abigael Muchenditsi, Aline Gottlieb, Pragney Deme, Sean Murphy, Kathleen L Gabrielson, Yixuan Dong, Robert Hughes, Norman J Haughey, James P Hamilton and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
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  10. α-lipoic acid ameliorates consequences of copper overload by up-regulating selenoproteins and decreasing redox misbalance.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Som DevDepartment of Physiology, Johns Hopkins University, School of Medicine, 725 North Wolfe St, Baltimore, MD 21205, USA.ORCID 0000-0003-1934-1019
Abigael MuchenditsiDepartment of Physiology, Johns Hopkins University, School of Medicine, 725 North Wolfe St, Baltimore, MD 21205, USA.
Aline GottliebDepartment of Physiology, Johns Hopkins University, School of Medicine, 725 North Wolfe St, Baltimore, MD 21205, USA.
Pragney DemeDepartment of Neurology, Johns Hopkins University, School of Medicine, 600 North Wolfe St, Baltimore, MD 21287, USA.ORCID 0000-0001-9117-891X
Sean MurphyDepartment of Biomedical Engineering, Johns Hopkins University, School of Medicine, 720 Rutland Ave, Baltimore, MD 21205, USA.ORCID 0000-0003-1960-2194
Kathleen L GabrielsonDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University, School of Medicine, 733 North Broadway, Baltimore, MD 21205, USA.ORCID 0000-0003-3901-4357
Yixuan DongDepartment of Physiology, Johns Hopkins University, School of Medicine, 725 North Wolfe St, Baltimore, MD 21205, USA.
Robert HughesDepartment of Medicine, Johns Hopkins University, School of Medicine, 733 North Broadway, Baltimore, MD 21205, USA.ORCID 0000-0002-4182-9136
Norman J HaugheyDepartment of Neurology, Johns Hopkins University, School of Medicine, 600 North Wolfe St, Baltimore, MD 21287, USA.ORCID 0000-0001-5194-4122
James P HamiltonDepartment of Medicine, Johns Hopkins University, School of Medicine, 733 North Broadway, Baltimore, MD 21205, USA.ORCID 0000-0003-3137-7567
Svetlana LutsenkoDepartment of Physiology, Johns Hopkins University, School of Medicine, 725 North Wolfe St, Baltimore, MD 21205, USA.ORCID 0000-0001-5275-2587
Johns Hopkins University · US

Funding

Copper Homeostasis and Liver FunctionR01DK117396 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI JAMES P HAMILTON, SVETLANA LUTSENKO · 2018 to 2026
$3.9M
NIDDK NIH HHS R01 DK117396
6 · The paper itself

Abstract

Wilson disease (WD) is a metabolic disorder caused by inactivation of the copper-transporting ATPase 2 (ATP7B) and copper (Cu) overload in tissues. Excess Cu causes oxidative stress and pathologic changes with poorly understood mechanistic connections. In

Identifiers

PMID36260680
PMCPMC9581482
OpenAlexW4306855765

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.