ReviewScience advances2022
The metabolomics of human aging: Advances, challenges, and opportunities.
Review in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
89 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Metabolomics in stress-related disorders: a systematic review and bioinformatics analysis.Naunyn-Schmiedeberg's archives of pharmacology · 2026Pooled it
- Machine learning and data-driven inverse modeling of metabolomics unveil key processes of active aging.NPJ systems biology and applications · 2025Trial
- Plasma Metabolomic Alterations Are Associated with T-Cell Senescence, Cytokine Dysregulation, and Prognosis in Elderly COVID-19 Patients.Biomedicines · 2026Article
- Urinary metabolomics data and cognitive performance in an adult population.Metabolic brain disease · 2026Article
- Sex-specific aging clocks from a large-scale human phenome reveal distinct aging transitions and circulating signatures.Nature aging · 2026Article
- Metabolic Phenotyping Identifies Responders to Sustainable Healthy Diets: Analysis from the MyPlanetDiet Randomized Controlled Trial.Current developments in nutrition · 2026Article
- Urinary metabolic age from high-resolution nuclear magnetic resonance spectroscopy reveals longitudinal aging patterns.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Research progress of traditional Chinese medicine interventions for aging-related nervous system diseases.Biogerontology · 2026Review
- Metabolomic ageing across mental and behavioural disorders.BMJ mental health · 2026Article
- Advanced technologies of single-cell metabolomics unveiling cellular metabolic heterogeneity for biological and biomedical research.Journal of food and drug analysis · 2026Review
- Metabolomic ageing (MileAge) in mid-life predicts incident vascular, unspecified and all-cause dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Multimodal analysis of molecular remodeling in aging spleen identified global and cell type specific changes.bioRxiv : the preprint server for biology · 2026Article
- Utility of biological aging markers for mortality risk stratification in community-dwelling older adults: insights from the Mr. OS and Ms. OS (Hong Kong) cohort.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Metabolomic signatures of extreme old age: findings from the New England Centenarian Study.GeroScience · 2026Article
- Blood biomarkers and breed genetics of aging in pet dogs.bioRxiv : the preprint server for biology · 2026Article
- Identification of plasma biomarkers in lipid metabolism for accurate prediction of Alzheimer's disease.Translational psychiatry · 2026Article
- Gut Microbiota Affects Age-Related Plasma Metabolites.Microorganisms · 2026Article
- OMICmAge quantifies biological age by integrating multi-omics with electronic medical records.Nature aging · 2026Article
- Lifespan-Extending Endogenous Metabolites.Aging cell · 2026Review
- Aging-linked systemic lipid signature is reprogrammed by caloric restriction in rhesus monkeys.Molecular systems biology · 2026Article
29 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
As the global population becomes older, understanding the impact of aging on health and disease becomes paramount. Recent advancements in multiomic technology have allowed for the high-throughput molecular characterization of aging at the population level. Metabolomics studies that analyze the small molecules in the body can provide biological information across a diversity of aging processes. Here, we review the growing body of population-scale metabolomics research on aging in humans, identifying the major trends in the field, implicated biological pathways, and how these pathways relate to health and aging. We conclude by assessing the main challenges in the research to date, opportunities for advancing the field, and the outlook for precision health applications.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.