ArticlePloS one2022
A community-science approach identifies genetic variants associated with three color morphs in ball pythons (Python regius).
Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 17 citations in OpenAlex.
- Genome Scanning Reveals the Genetic Basis of a Color Pattern Morphotype in an Island Population of the European Adder (Vipera berus).Genome biology and evolution · 2026Article
- Epidemiological investigation and genetic characterization of Coxiella burnetii carried by parasitic ticks in the southeastern coastal region of China.BMC infectious diseases · 2026Article
- Article
- Metalation and activation of ZnBiophysics reviews · 2023Review
- Stripes and loss of color in ball pythons (Python regius) are associated with variants affecting endothelin signaling.G3 (Bethesda, Md.) · 2023Article
- Piebaldism and chromatophore development in reptiles are linked to the tfec gene.Current biology : CB · 2023Article
- A frameshift variant in the melanophilin gene is associated with loss of pigment from shed skin in ball pythons (microPublication biology · 2023Article
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Authors and funding
9 authors at 1 institution in 1 country.
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Abstract
Color morphs in ball pythons (Python regius) provide a unique and largely untapped resource for understanding the genetics of coloration in reptiles. Here we use a community-science approach to investigate the genetics of three color morphs affecting production of the pigment melanin. These morphs-Albino, Lavender Albino, and Ultramel-show a loss of melanin in the skin and eyes, ranging from severe (Albino) to moderate (Lavender Albino) to mild (Ultramel). To identify genetic variants causing each morph, we recruited shed skins of pet ball pythons via social media, extracted DNA from the skins, and searched for putative loss-of-function variants in homologs of genes controlling melanin production in other vertebrates. We report that the Albino morph is associated with missense and non-coding variants in the gene TYR. The Lavender Albino morph is associated with a deletion in the gene OCA2. The Ultramel morph is associated with a missense variant and a putative deletion in the gene TYRP1. Our study is one of the first to identify genetic variants associated with color morphs in ball pythons and shows that pet samples recruited from the community can provide a resource for genetic studies in this species.
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