ArticleIEEE transactions on bio-medical engineering2023
Simultaneous Assessment of the Whole Eye Biomechanics Using Ultrasonic Elastography.
Article in IEEE transactions on bio-medical engineering, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 66 citations in OpenAlex.
- Phantoms for use in optical coherence elastography.Journal of biomedical optics · 2026Review
- Transformative biomechanics and mechanobiology breakthroughs shaping the future of health and medicine.Innovation (Cambridge (Mass.)) · 2026Review
- Four-Dimensional Sequential Elastography for Ocular Tissue Using 2D Matrix Array.BME frontiers · 2026Article
- Multiscale analysis of equatorial sclera anisotropy: Revealing discrepancies in fiber orientation and mechanical properties.Science advances · 2025Article
- Optical Coherence Elastography Measures Mechanical Tension in the Lens and Capsule.Acta biomaterialia · 2025Article
- Analysis wave speed of optic nerve and optic nerve head for assessing normal tension glaucoma by using vibro-elastography technique.Clinical biomechanics (Bristol, Avon) · 2025Article
- Four-Dimensional (4D) Ultrasound Shear Wave Elastography Using Sequential Excitation.IEEE transactions on bio-medical engineering · 2025Article
- Viscoelasticity in 3D Cell Culture and Regenerative Medicine: Measurement Techniques and Biological Relevance.ACS materials Au · 2024Review
- Compound Acoustic Radiation Force Impulse Imaging of Bovine Eye by Using Phase-Inverted Ultrasound Transducer.Sensors (Basel, Switzerland) · 2024Article
- Optic Nerve Head Pulsatile Displacement in Open-Angle Glaucoma after Intraocular Pressure Reduction Measured by Optical Coherence Tomography: A Pilot Study.Bioengineering (Basel, Switzerland) · 2024Article
- Corneal biomechanics and diagnostics: a review.International ophthalmology · 2024Review
- Investigation of How Corneal Densitometry Artefacts Affect the Imaging of Normal and Keratoconic Corneas.Bioengineering (Basel, Switzerland) · 2024Article
- In Vivo Evaluation of Corneal Biomechanics Following Cross-Linking Surgeries Using Optical Coherence Elastography in a Rabbit Model of Keratoconus.Translational vision science & technology · 2024Article
- Short-Term Outcomes of XEN45 Standalone versus Combined with Phacoemulsification in Open-Angle Glaucoma Patients: A Retrospective Study.Journal of clinical medicine · 2023Article
- Noncontact longitudinal shear wave imaging for the evaluation of heterogeneous porcine brain biomechanical properties using optical coherence elastography.Biomedical optics express · 2023Article
- Possible depth-resolved reconstruction of shear moduli in the cornea following collagen crosslinking (CXL) with optical coherence tomography and elastography.Biomedical optics express · 2023Article
- Multifocal acoustic radiation force-based reverberant optical coherence elastography for evaluation of ocular globe biomechanical properties.Journal of biomedical optics · 2023Article
- Oxidative Stress: A Suitable Therapeutic Target for Optic Nerve Diseases?Antioxidants (Basel, Switzerland) · 2023Review
- Article
- Non-Invasive Hybrid Ultrasound Stimulation of Visual Cortex In Vivo.Bioengineering (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
objectiveCurrent elastography techniques in the field of ophthalmology usually target one specific tissue, such as the cornea or the sclera. However, the eye is an inter-related organ, and some ocular diseases can alter the biomechanical properties of multiple anatomical structures. Hence, there is a need to develop an imaging tool that can non-invasively, quantitatively, and accurately characterize dynamic changes among these biomechanical properties.
methodsA high resolution ultrasound elastography system was developed to achieve this goal. The efficacy and accuracy of the system was first validated on tissue-mimicking phantoms while mechanical testing measurements served as the gold standard. Next, an in vivo elevated intraocular pressure (IOP) model was established in rabbits to further test our system. In particular, elastography measurements were obtained at 5 IOP levels, ranging from 10 mmHg to 30 mmHg in 5 mmHg increments. Spatial-temporal maps of the multiple ocular tissues (cornea, lens, iris, optic nerve head, and peripapillary sclera) were obtained.
resultsThe spatial-temporal maps were acquired simultaneously for the ocular tissues at the 5 different IOP levels. The statistical analysis of the elastic wave speed was presented for ocular tissues. Finally, the mapping for the elastic wave speed of each ocular component was acquired at each IOP level.
conclusionOur elastography system can concurrently assess the biomechanical properties of multiple ocular structures and detect changes in biomechanical properties associated with changes in IOP. SIGNIFICANCE: This system provides a novel tool to measure and quantify the biomechanical properties of the whole eye.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.