ArticleAngewandte Chemie (International ed. in English)2022
Ultrafast Dynamics and Catalytic Mechanism of Fatty Acid Photodecarboxylase.
Article in Angewandte Chemie (International ed. in English), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Molecular Mechanism of the Catalytic Radical Termination in Fatty Acid Photodecarboxylase.Journal of the American Chemical Society · 2026Article
- On the Origin of the Red-Shifted Flavin Absorption Spectra in Fatty Acid Photodecarboxylase.The journal of physical chemistry. B · 2026Article
- Ultrafast photooxidation of semireduced flavin in fatty acid photodecarboxylase.Science advances · 2025Article
- Light-Driven Enzyme Catalysis: Ultrafast Mechanisms and Biochemical Implications.Biochemistry · 2025Review
- Transitioning enzyme catalysis towards photocatalysis.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2025Review
- Article
- Decarboxylation in Natural Products Biosynthesis.JACS Au · 2024Review
- Photoinduced Electron Transfer from a 1,4,5,6-Tetrahydro Nicotinamide Adenine Dinucleotide (Phosphate) Analogue to Oxidized Flavin in an Ene-Reductase Flavoenzyme.The journal of physical chemistry letters · 2023Article
- Ultrafast Dynamics and Catalytic Mechanism of Fatty Acid Photodecarboxylase.Angewandte Chemie (International ed. in English) · 2022Article
- Ultrafast Dynamics of Fatty Acid Photodecarboxylase in Anionic Semiquinone State.The journal of physical chemistry letters · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Fatty acid photodecarboxylase is a newly discovered flavin photoenzyme that converts a carboxylic acid into a hydrocarbon and a carbon dioxide molecule through decarboxylation. The enzymatic reactions are poorly understood. In this study, we carefully characterized its dynamic evolution with femtosecond spectroscopy. We observed initial electron transfer from the substrate to the flavin cofactor in 347 ps with a stretched dynamic behavior and subsequently captured the critical carbonyloxy radical. The dominant process following this step was decarboxylation in 5.8 ns to form an alkyl radical and a carbon dioxide molecule. We further identified the absorption bands of two carbonyloxy and alkyl radical intermediates. The overall enzymatic quantum efficiency determined by our obtained timescales is 0.81, consistent with the steady-state value. The results are essential to the elucidation of the enzyme mechanism and catalytic photocycle, providing a molecular basis for potential design of flavin-based artificial photoenzymes.
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