Evidence map›Paper›PMID 36260333›Full record

ArticleJAMA network open2022

Association of Intravenous Potassium and Magnesium Administration With Spontaneous Conversion of Atrial Fibrillation and Atrial Flutter in the Emergency Department.

Filippo Cacioppo, Denise Reisenbauer, Harald Herkner, Julia Oppenauer, Nikola Schuetz, Jan Niederdoeckl, Sebastian Schnaubelt, Sophie Gupta, Martin Lutnik, Alexander Simon and 5 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in JAMA network open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Filippo CacioppoDepartment of Emergency Medicine, Medical University of Vienna, Vienna, Austria.
Denise ReisenbauerDepartment of Emergency Medicine, Medical University of Vienna, Vienna, Austria.
Harald HerknerDepartment of Emergency Medicine, Medical University of Vienna, Vienna, Austria.
Julia OppenauerDepartment of Emergency Medicine, Medical University of Vienna, Vienna, Austria.
Nikola SchuetzDepartment of Emergency Medicine, Medical University of Vienna, Vienna, Austria.
Jan NiederdoecklDepartment of Emergency Medicine, Medical University of Vienna, Vienna, Austria.
Sebastian SchnaubeltDepartment of Emergency Medicine, Medical University of Vienna, Vienna, Austria.
Sophie GuptaDepartment of Emergency Medicine, Medical University of Vienna, Vienna, Austria.
Martin LutnikDepartment of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.
Alexander SimonDepartment of Emergency Medicine, Clinic Ottakring, Vienna, Austria.
Alexander O SpielDepartment of Emergency Medicine, Clinic Ottakring, Vienna, Austria.
Nina BuchteleDepartment of Medicine I, 13i2, Medical University of Vienna, Vienna, Austria.
Hans DomanovitsDepartment of Emergency Medicine, Medical University of Vienna, Vienna, Austria.
Anton N LaggnerDepartment of Emergency Medicine, Medical University of Vienna, Vienna, Austria.
Michael SchwameisDepartment of Emergency Medicine, Medical University of Vienna, Vienna, Austria.
Medical University of Vienna · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Importance: Whether the simultaneous intravenous administration of potassium and magnesium is associated with the probability of spontaneous conversion to sinus rhythm (SCV) in the acute treatment of atrial fibrillation (AF) and atrial flutter (AFL) is unknown. Objective: To assess potassium and magnesium administration and SCV probability in AF and AFL in the emergency department. Design, Setting, and Participants: A registry-based cohort study was conducted in the Department of Emergency Medicine of the Medical University of Vienna, Austria. All consecutive patients with AF or AFL were screened between February 6, 2009, and February 16, 2020. Interventions: Intravenous administration of potassium, 24 mEq, and magnesium, 145.8 mg. Main Outcomes and Measures: The primary outcome was the probability of SCV during the patient's stay in the emergency department. Multivariable cluster-adjusted logistic regression was used to estimate the association between potassium and magnesium administration and the probability of SCV. Results: A total of 2546 episodes of nonpermanent AF (median patient age, 68 [IQR, 58-75] years, 1411 [55.4%] men) and 573 episodes of nonpermanent AFL (median patient age, 68 [IQR, 58-75] years; 332 [57.9%] men) were observed. In AF episodes, intravenous potassium and magnesium administration vs no administration was associated with increased odds of SCV (19.2% vs 10.4%; odds ratio [OR], 1.98; 95% CI, 1.53-2.57). In AFL episodes, in contrast, no association was noted for the probability of SCV with potassium and magnesium vs no administration (13.0% vs 12.5%; OR, 1.05; 95% CI, 0.65-1.69). Conclusions and Relevance: The findings of this registry-based cohort study on intravenous administration of potassium and magnesium suggest an increased probability of SCV in nonpermanent AF, but not AFL, during a patients' stay in the emergency department.

Indexed as

Atrial FibrillationAtrial FlutterAgedCohort StudiesEmergency Service, HospitalFemaleHumansMagnesiumMalePotassiumTreatment OutcomeMagnesiumPotassium

Identifiers

PMID36260333
PMCPMC9582905
OpenAlexW4306803533

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.