Evidence map›Paper›PMID 36260209›Full record

ReviewJournal of muscle research and cell motility2023

John squire and endothelial glycocalyx structure: an unfinished story.

Kenton P Arkill, C Charles Michel, Elizabeth V M Rider, Elise A Wood, Mathew O Small, Jennifer L E Brown, Abigail L Kinnaird

Open access · hybridAbstract readReview
In one paragraph

Review in Journal of muscle research and cell motility, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Glycosaminoglycans and Their Role in Capillary Walls.Advances in experimental medicine and biology · 2026
    Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Kenton P ArkillSchool of Medicine, University of Nottingham Biodiscovery Institute, Nottingham, UK. kenton.arkill@nottingham.ac.uk.ORCID 0000-0002-3360-6055
C Charles MichelDepartment of Bioengineering, Imperial College London, London, UK. c.c.michel@imperial.ac.uk.
Elizabeth V M RiderSchool of Medicine, University of Nottingham Biodiscovery Institute, Nottingham, UK.
Elise A WoodSchool of Medicine, University of Nottingham Biodiscovery Institute, Nottingham, UK.
Mathew O SmallSchool of Medicine, University of Nottingham Biodiscovery Institute, Nottingham, UK.
Jennifer L E BrownSchool of Medicine, University of Nottingham Biodiscovery Institute, Nottingham, UK.
Abigail L KinnairdSchool of Medicine, University of Nottingham Biodiscovery Institute, Nottingham, UK.
University of Nottingham · GBImperial College London · GB

Funding

Medical Research Council MR/P003214/1
6 · The paper itself

Abstract

John Squire did not only produce leading works in the muscle field, he also significantly contributed to the vascular permeability field by ultrastructural analysis of the endothelial glycocalyx. Presented here is a review of his involvement in the field by his main collaborator C.C. Michel and his last postdoctoral researcher KP Arkill. We end on a reinterpretation of his work that arguably links to our current understanding of endothelial glycocalyx structure and composition predicting 6 glycosaminoglycans fibres per syndecan core protein, only achieved in the endothelium by dimerization.

Indexed as

GlycocalyxGlycosaminoglycansHumansMaleGlycosaminoglycansAlbuminGlycosaminoglycanProteoglycanReflection coefficientVascular permeability

Identifiers

PMID36260209
PMCPMC10542707
OpenAlexW4306774045

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.