ArticleEuropean journal of epidemiology2022
Framework and baseline examination of the German National Cohort (NAKO).
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Article in European journal of epidemiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 117 papers.
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117citing papers in PubMed
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Who cites it
117 citing papers in PubMed.
- Prospective cohort study for digital health research in Germany (DigiHero): objectives, design and baseline characteristics.European journal of epidemiology · 2026Article
- How a 10-minute bout requirement for physical activity affects guideline adherence estimates, Germany.Bulletin of the World Health Organization · 2026Article
- Occupational differences in sickness presenteeism in the baseline survey of the German National Cohort (NAKO).Journal of occupational medicine and toxicology (London, England) · 2026Article
- Intensity-specific physical activity and mortality in 147,414 adults: a pooled accelerometer analysis.The international journal of behavioral nutrition and physical activity · 2026Article
- Childhood maltreatment and adult blood pressure-based outcomes: age- and sex-specific associations in the German National Cohort (NAKO).BMC public health · 2026Article
- Physical activity and type 2 diabetes risk: Heterogeneity in the dose-response by obesity and age.Medicine · 2026Article
- Polypharmacy Among 200 000 Subjects of the Population-Based German National Cohort Study (NAKO), Aged 19-74: A Baseline Analysis.Deutsches Arzteblatt international · 2026Observational
- Socioeconomic Status, Alcohol Use, and Mortality: Results From a Prospective Cohort Study.Alcohol, clinical & experimental research · 2026Article
- Volumetric reference data of the orbit: a deep learning MRI analysis in the German national cohort.Scientific reports · 2026Article
- Pooled two-cohort MRI body composition phenotyping with open-source deep learning.Communications medicine · 2026Article
- Assessing the change in diet from baseline to first re-examination - results from the German National Cohort (NAKO).BMC nutrition · 2026Article
- Can synthetic data reproduce real-world findings in epidemiology? A replication study using adversarial random forests.International journal of epidemiology · 2026Article
- Ascertainment of Cancer Cases in the German National Cohort (NAKO): Methods and Initial Results.Deutsches Arzteblatt international · 2026Observational
- Psychosocial stress from pre- to post-pandemic times: latent class mixed model analysis using data from a German cohort.Social psychiatry and psychiatric epidemiology · 2026Article
- Statistical methods for retrospective harmonization of longitudinal epidemiological data: a scoping review.European journal of epidemiology · 2026Article
- Opportunistic screening for incident cardiometabolic disease in metabolically healthy non-obese individuals: a prospective cohort study.Cardiovascular diabetology · 2026Article
- Linking the exposome to the brain-behaviour phenotype.Nature reviews. Neuroscience · 2026Review
- A comprehensive assessment of lifecourse and mortality of Parkinson's disease in the German National Cohort.NPJ Parkinson's disease · 2026Article
- Glomerular Filtration Rate, Albuminuria, and Reported Kidney Disease in Comparison: Results From the German National Cohort (NAKO).Deutsches Arzteblatt international · 2026Observational
- DNAm landscape up to 4 months post SARS-CoV-2 infection: insights from four population-based cohorts.Clinical epigenetics · 2026Article
57 more citing papers are in PubMed but not listed here.
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Authors and funding
130 authors.
Annette PetersInstitute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health (GmbH), Ingolstädter Landstr. 1, 85764, Neuherberg, Germany. peters@helmholtz-muenchen.de.ORCID http://orcid.org/0000-0001-6645-0985
German National Cohort (NAKO) Consortium
Annette PetersInstitute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health (GmbH), Ingolstädter Landstr. 1, 85764, Neuherberg, Germany.
Karin Halina GreiserGerman Cancer Research Center in the Helmholtz Association DKFZ, Heidelberg, Germany.
Susanne GöttlicherInstitute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health (GmbH), Ingolstädter Landstr. 1, 85764, Neuherberg, Germany.
Wolfgang AhrensLeibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany.
Maren AlbrechtNAKO e.V., Am Taubenfeld 21/2, 69123, Heidelberg, Germany.
Fabian BambergDepartment of Diagnostic and Interventional Radiology, Medical Center, Faculty of Medicine Freiburg, University of Freiburg, Freiburg, Germany.
Till BärnighausenHeidelberg University Hospital, Heidelberg, Germany.
Heiko BecherUniversity Medical Center Hamburg Eppendorf, Hamburg, Germany.
Klaus BergerInstitute of Epidemiology and Social Medicine, University of Münster, Münster, Germany.
Achim BeuleDepartment of Otorhinolaryngology, University Hospital Münster, Münster, Germany.
Heiner BoeingDepartment of Epidemiology (Closed), German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany.
Barbara BohnNAKO e.V., Am Taubenfeld 21/2, 69123, Heidelberg, Germany.
Kerstin BohnertNAKO e.V., Am Taubenfeld 21/2, 69123, Heidelberg, Germany.
Bettina BraunInstitute of Epidemiology and Social Medicine, University of Münster, Münster, Germany.
Hermann BrennerGerman Cancer Research Center in the Helmholtz Association DKFZ, Heidelberg, Germany.
Robin BülowInstitute for Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany.
Stefanie CastellHelmholtz Center for Infection Research, Brunswick, Germany.
Antje Damms-MachadoGerman Cancer Research Center in the Helmholtz Association DKFZ, Heidelberg, Germany.
Marcus DörrDepartment of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.
Nina EbertGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Margit EckerDepartment of Diagnostic and Interventional Radiology, Medical Center, Faculty of Medicine Freiburg, University of Freiburg, Freiburg, Germany.
Carina EmmelInstitute for Medical Informatics, Biometry and Epidemiology, Essen University Hospital, Essen, Germany.
Beate FischerUniversity of Regensburg, Regensburg, Germany.
Claus-Werner FranzkeInstitute for Prevention and Cancer Epidemiology, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany.
Sylvia GastellGerman Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany.
Guido GianiGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Matthias GüntherFraunhofer Institute for Digital Medicine MEVIS, Bremen, Germany.
Kathrin GüntherLeibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany.
Klaus-Peter GüntherUniversity Center of Orthopaedics, Traumatology and Plastic Surgery at the Technische Universität Dresden, Dresden, Germany.
Johannes HaertingInstitute of Medical Epidemiology, Biostatistics, and Informatics, Medical Faculty of the Martin-Luther University Halle-Wittenberg, Halle, Germany.
Ulrike HaugLeibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany.
Iris M HeidDepartment of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
Margit HeierInstitute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health (GmbH), Ingolstädter Landstr. 1, 85764, Neuherberg, Germany.
Diana HeinemeyerNAKO e.V., Am Taubenfeld 21/2, 69123, Heidelberg, Germany.
Thomas HendelInstitute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health (GmbH), Ingolstädter Landstr. 1, 85764, Neuherberg, Germany.
Florian HerbolsheimerGerman Cancer Research Center in the Helmholtz Association DKFZ, Heidelberg, Germany.
Jochen HirschFraunhofer Institute for Digital Medicine MEVIS, Bremen, Germany.
Wolfgang HoffmannInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Bernd HolleczekKrebsregister Saarland, Saarbrücken, Germany.
Heike HöllingRobert Koch-Institut, Berlin, Germany.
Andreas HörleinInstitute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health (GmbH), Ingolstädter Landstr. 1, 85764, Neuherberg, Germany.
Karl-Heinz JöckelInstitute for Medical Informatics, Biometry and Epidemiology, Essen University Hospital, Essen, Germany.
Rudolf KaaksGerman Cancer Research Center in the Helmholtz Association DKFZ, Heidelberg, Germany.
André KarchInstitute of Epidemiology and Social Medicine, University of Münster, Münster, Germany.
Stefan KarraschInstitute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health (GmbH), Ingolstädter Landstr. 1, 85764, Neuherberg, Germany.
Nadja KartschmitInstitute of Medical Epidemiology, Biostatistics, and Informatics, Medical Faculty of the Martin-Luther University Halle-Wittenberg, Halle, Germany.
Hans-Ulrich KauczorHeidelberg University Hospital, Heidelberg, Germany.
Thomas KeilInstitute of Social Medicine, Epidemiology and Health Economics, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Yvonne KemmlingHelmholtz Center for Infection Research, Brunswick, Germany.
Bianca KleeInstitute of Medical Epidemiology, Biostatistics, and Informatics, Medical Faculty of the Martin-Luther University Halle-Wittenberg, Halle, Germany.
Birgit KlüppelholzGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Alexander KluttigInstitute of Medical Epidemiology, Biostatistics, and Informatics, Medical Faculty of the Martin-Luther University Halle-Wittenberg, Halle, Germany.
Lisa KofinkNAKO e.V., Am Taubenfeld 21/2, 69123, Heidelberg, Germany.
Anna KöttgenInstitute of Genetic Epidemiology, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany.
Daniel KraftGerman Cancer Research Center in the Helmholtz Association DKFZ, Heidelberg, Germany.
Gérard KrauseHelmholtz Center for Infection Research, Brunswick, Germany.
Lisa KretzDepartment of Diagnostic and Interventional Radiology, Medical Center, Faculty of Medicine Freiburg, University of Freiburg, Freiburg, Germany.
Lilian KristInstitute of Social Medicine, Epidemiology and Health Economics, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Jan KühnischDepartment of Conservative Dentistry and Periodontology, University Hospital, School of Dentistry, Ludwig-Maximilians-Universität München, Munich, Germany.
Oliver KußGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Nicole LegathInstitute of Epidemiology and Social Medicine, University of Münster, Münster, Germany.
Anna-Therese LehnichGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Michael LeitzmannUniversity of Regensburg, Regensburg, Germany.
Wolfgang LiebInstitute of Epidemiology, University of Kiel, Kiel, Germany.
Jakob LinseisenHelmholtz Zentrum München - German Research Center for Environmental Health (GmbH), Neuherberg, Germany.
Markus LoefflerUniversity of Leipzig, Leipzig, Germany.
Anke MacdonaldNAKO e.V., Am Taubenfeld 21/2, 69123, Heidelberg, Germany.
Klaus H Maier-HeinGerman Cancer Research Center in the Helmholtz Association DKFZ, Heidelberg, Germany.
Nina MangoldChair of Epidemiology, Institute for Medical Information Processing, Biometry and Epidemiology, Medical Faculty, Ludwig-Maximilians-Universität München, Munich, Germany.
Claudia Meinke-FranzeInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Christa MeisingerChair of Epidemiology, Institute for Medical Information Processing, Biometry and Epidemiology, Medical Faculty, Ludwig-Maximilians-Universität München, Munich, Germany.
Juliane MelzerGerman Cancer Research Center in the Helmholtz Association DKFZ, Heidelberg, Germany.
Björn MergartenNAKO e.V., Am Taubenfeld 21/2, 69123, Heidelberg, Germany.
Karin B MichelsInstitute for Prevention and Cancer Epidemiology, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany.
Rafael MikolajczykInstitute of Medical Epidemiology, Biostatistics, and Informatics, Medical Faculty of the Martin-Luther University Halle-Wittenberg, Halle, Germany.
Susanne MoebusInstitute for Urban Public Health, Essen University Hospital, Essen, Germany.
Ulrich MuellerFederal Institute for Population Research, Wiesbaden, Germany.
Matthias NauckInstitute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.
Thoralf NiendorfMax-Delbrueck Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
Konstantin NikolaouDepartment of Diagnostic and Interventional Radiology, Eberhard Karls Universität Tübingen, Tübingen, Germany.
Nadia ObiUniversity Medical Center Hamburg Eppendorf, Hamburg, Germany.
Stefan OstrzinskiInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Leo PanreckNAKO e.V., Am Taubenfeld 21/2, 69123, Heidelberg, Germany.
Iris PigeotLeibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany.
Tobias PischonMolecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.
Irene Pschibul-ThammInstitute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health (GmbH), Ingolstädter Landstr. 1, 85764, Neuherberg, Germany.
Wolfgang RathmannGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Achim ReinekeLeibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany.
Stefanie RoloffHospital St. Marienstift Magdeburg GmbH, Magdeburg, Germany.
Dan RujescuMedical University of Vienna, Vienna, Austria.
Stefan RupfChair of Synoptic Dentistry, Saarland University, Saarbrücken, Germany.
Oliver SanderDepartment of Rheumatology, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Tamara SchikowskiIUF - Leibniz Research Institute for Environmental Medicine, Duesseldorf, Germany.
Sabine SchipfInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Peter SchirmacherHeidelberg University Hospital, Heidelberg, Germany.
Christopher L SchlettDepartment of Diagnostic and Interventional Radiology, Medical Center, Faculty of Medicine Freiburg, University of Freiburg, Freiburg, Germany.
Börge SchmidtInstitute for Medical Informatics, Biometry and Epidemiology, Essen University Hospital, Essen, Germany.
Georg SchmidtDepartment of Internal Medicine 1, Klinikum rechts der Isar, Technical University Munich, Munich, Germany.
Martin SchmidtGerman Cancer Research Center in the Helmholtz Association DKFZ, Heidelberg, Germany.
Gina SchöneRobert Koch-Institut, Berlin, Germany.
Holger SchulzInstitute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health (GmbH), Ingolstädter Landstr. 1, 85764, Neuherberg, Germany.
Matthias B SchulzeGerman Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany.
Alexandra SchweigDepartment of Ophthalmology, Tübingen University Hospital, Tübingen, Germany.
Anja M SedlmeierUniversity of Regensburg, Regensburg, Germany.
Sonja SelderDepartment of Radiology, Ludwig-Maximilians-University Hospital, Munich, Germany.
Julia Six-MerkerInstitute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health (GmbH), Ingolstädter Landstr. 1, 85764, Neuherberg, Germany.
Ramona SowadeHeidelberg University Hospital, Heidelberg, Germany.
Andreas StangInstitute for Medical Informatics, Biometry and Epidemiology, Essen University Hospital, Essen, Germany.
Oliver StegleGerman Cancer Research Center in the Helmholtz Association DKFZ, Heidelberg, Germany.
Karen SteindorfGerman Cancer Research Center in the Helmholtz Association DKFZ, Heidelberg, Germany.
Gunthard StübsInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Enno SwartInstitute of Social Medicine and Health Systems Research, Med. Faculty, Otto-Von-Guericke-University Magdeburg, Magdeburg, Germany.
Henning TeismannInstitute of Epidemiology and Social Medicine, University of Münster, Münster, Germany.
Inke ThieleInstitute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health (GmbH), Ingolstädter Landstr. 1, 85764, Neuherberg, Germany.
Sigrid ThierryInstitute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health (GmbH), Ingolstädter Landstr. 1, 85764, Neuherberg, Germany.
Marius UeffingInstitute for Ophthalmic Research, Tübingen University Hospital, Tübingen, Germany.
Henry VölzkeInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Sabina WaniekInstitute of Epidemiology, University of Kiel, Kiel, Germany.
Andrea WeberUniversity of Regensburg, Regensburg, Germany.
Nicole WernerInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
H-Erich WichmannInstitute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health (GmbH), Ingolstädter Landstr. 1, 85764, Neuherberg, Germany.
Stefan N WillichInstitute of Social Medicine, Epidemiology and Health Economics, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Kerstin WirknerUniversity of Leipzig, Leipzig, Germany.
Kathrin WolfInstitute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health (GmbH), Ingolstädter Landstr. 1, 85764, Neuherberg, Germany.
Robert WolffInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Hajo ZeebLeibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany.
Melanie ZinkhanMartin-Luther-University, Halle, Germany.
Johannes ZschockeInstitute of Medical Epidemiology, Biostatistics, and Informatics, Medical Faculty of the Martin-Luther University Halle-Wittenberg, Halle, Germany.
Funding
Bundesministerium für Bildung und Forschung 01ER1301A/B/CBundesministerium für Bildung und Forschung 01ER1511D
Abstract
The German National Cohort (NAKO) is a multidisciplinary, population-based prospective cohort study that aims to investigate the causes of widespread diseases, identify risk factors and improve early detection and prevention of disease. Specifically, NAKO is designed to identify novel and better characterize established risk and protection factors for the development of cardiovascular diseases, cancer, diabetes, neurodegenerative and psychiatric diseases, musculoskeletal diseases, respiratory and infectious diseases in a random sample of the general population. Between 2014 and 2019, a total of 205,415 men and women aged 19-74 years were recruited and examined in 18 study centres in Germany. The baseline assessment included a face-to-face interview, self-administered questionnaires and a wide range of biomedical examinations. Biomaterials were collected from all participants including serum, EDTA plasma, buffy coats, RNA and erythrocytes, urine, saliva, nasal swabs and stool. In 56,971 participants, an intensified examination programme was implemented. Whole-body 3T magnetic resonance imaging was performed in 30,861 participants on dedicated scanners. NAKO collects follow-up information on incident diseases through a combination of active follow-up using self-report via written questionnaires at 2-3 year intervals and passive follow-up via record linkages. All study participants are invited for re-examinations at the study centres in 4-5 year intervals. Thereby, longitudinal information on changes in risk factor profiles and in vascular, cardiac, metabolic, neurocognitive, pulmonary and sensory function is collected. NAKO is a major resource for population-based epidemiology to identify new and tailored strategies for early detection, prediction, prevention and treatment of major diseases for the next 30 years.
Indexed as
Prospective StudiesCohort StudiesFemaleGermanyHumansMaleSelf ReportSurveys and QuestionnairesCommunicable diseasesEpidemiologyFunctional impairmentsLife-style and socio-economic factorsMagnetic resonance imagingNon-communicable diseasesPopulation-based cohortPre-clinical diseasePsychosocial factors
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