Evidence map›Paper›PMID 36260174›Full record

ArticlePflugers Archiv : European journal of physiology2023

Two firing modes and well-resolved Na

Andrea Marcantoni, Giuseppe Chiantia, Giulia Tomagra, Enis Hidisoglu, Claudio Franchino, Valentina Carabelli, Emilio Carbone

Erratum issuedOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pflugers Archiv : European journal of physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Forty years of the adrenal chromaffin cell through ISCCB meetings around the world.Pflugers Archiv : European journal of physiology · 2023
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Andrea MarcantoniDepartment of Drug Science, Laboratory of Cell Physiology and Molecular Neuroscience, N.I.S. Centre, University of Torino, Corso Raffaello 30, 10125, Turin, Italy. andrea.marcantoni@unito.it.
Giuseppe ChiantiaDepartment of Neuroscience, University of Torino, 10125, Turin, Italy.
Giulia TomagraDepartment of Drug Science, Laboratory of Cell Physiology and Molecular Neuroscience, N.I.S. Centre, University of Torino, Corso Raffaello 30, 10125, Turin, Italy.
Enis HidisogluDepartment of Drug Science, Laboratory of Cell Physiology and Molecular Neuroscience, N.I.S. Centre, University of Torino, Corso Raffaello 30, 10125, Turin, Italy.
Claudio FranchinoDepartment of Drug Science, Laboratory of Cell Physiology and Molecular Neuroscience, N.I.S. Centre, University of Torino, Corso Raffaello 30, 10125, Turin, Italy.
Valentina CarabelliDepartment of Drug Science, Laboratory of Cell Physiology and Molecular Neuroscience, N.I.S. Centre, University of Torino, Corso Raffaello 30, 10125, Turin, Italy.
Emilio CarboneDepartment of Drug Science, Laboratory of Cell Physiology and Molecular Neuroscience, N.I.S. Centre, University of Torino, Corso Raffaello 30, 10125, Turin, Italy. emilio.carbone@unito.it.
University of Turin · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We recorded spontaneous extracellular action potentials (eAPs) from rat chromaffin cells (CCs) at 37 °C using microelectrode arrays (MEAs) and compared them with intracellularly recorded APs (iAPs) through conventional patch clamp recordings at 22 °C. We show the existence of two distinct firing modes on MEAs: a ~ 4 Hz irregular continuous firing and a frequent intermittent firing mode where periods of high-intraburst frequency (~ 8 Hz) of ~ 7 s duration are interrupted by silent periods of ~ 12 s. eAPs occurred either as negative- or positive-going signals depending on the contact between cell and microelectrode: either predominantly controlled by junction-membrane ion channels (negative-going) or capacitive/ohmic coupling (positive-going). Negative-going eAPs were found to represent the trajectory of the Na

Indexed as

Chromaffin CellsLarge-Conductance Calcium-Activated Potassium ChannelsAction PotentialsAnimalsIon ChannelsMicroelectrodesRatsIon ChannelsLarge-Conductance Calcium-Activated Potassium ChannelsAP-clamp recordingCell-electrode interfaceExtracellular action potentialsIon channel blockersNa+, Ca2+, and K+ currents

Identifiers

PMID36260174
PMCPMC9849155
OpenAlexW4306793111

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.